Evidence-Based Complementary and Alternative Medicine

Research Article

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Table 6

Anti-inflammatory effect of the solvent fractions of A. mexicana fruits on cotton pellet-induced granuloma in rats.


Treatment group	BV (ml)	Change in paw volume (mean ± S.E.M) (ml) (percent inhibition (%))
Treatment group	BV (ml)	1 hour	2 hours	3 hours	4 hours

2% tween	0.22 ± 0.1	0.43 ± 0.02	0.44 ± 0.03	0.42 ± 0.03	0.40 ± 0.03
Aspirin, 200 mg/kg	0.21 ± 0.1	0.28 ± 0.04^abcd (30.89)	0.25 ± 0.04^abcde (41.44)	0.21 ± 0.03^abcde (50)	0.17 ± 0.02^#abcd (56)
100 mg/kg AF	0.20 ± 0.01	0.39 ± 0.04 (3.85)	0.38 ± 0.04 (14.67)	0.36 ± 0.03 (14.92)	0.35 ± 0.03 (22.50)
200 mg/kg AF	0.20 ± 0.01	0.37 ± 0.01 (8.55)	0.34 ± 0.01^a (27.41)	0.31 ± 0.1^a (37.09)	0.27 ± 0.03^a (45)
400 mg/kg AF	0.21 ± 0.01	0.32 ± 0.01^ab (20.94)	.30 ± 0.03^ab (29.34)	0.28 ± 0.03^ab (42.34)	0.23 ± 0.01^ab (45.83)
100 mg/kg n-HF	0.22 ± 0.01	0.36 ± 0.05^a (13.01)	0.36 ± 0.06^a (17.87)	0.33 ± 0.06^a (26.63)	0.28 ± 0.02^ab (31.54)
200 mg/kg n-HF	0.22 ± 0.01	0.34 ± 0.05^a (16.26)	0.35 ± 0.03^a (21.29)	0.30 ± 0.01^a (28.57)	0.26 ± 0.01^ab (35.27)
400 mg/kg n-HF	0.21 ± 0.02	0.29 ± 0.02^abc (28.05)	0.28 ± 0.02^abe (37.26)	0.29 ± 0.10^abc (43)	0.22 ± 0.01^ab (44.81)
100 mg/kg EAF	0.22 ± 0.01	0.34 ± 0.04^a (18.29)	0.32 ± 0.03^a (27.37)	0.28 ± 0.03^a (33.33)	0.26 ± 0.02^ab (34.85)
200 mg/kg EAF	0.21 ± 0.01	0.29 ± 0.04^abc (27.64)	0.26 ± 0.05^abcde (41.01)	0.22 ± 0.05^abcd (47.62)	0.18 ± 0.06^abc (54.36)
400 mg/kg EAF	0.21 ± 0.01	0.26 ± 0.02^abcde (35.77)	0.22 ± 0.01^abcde (48.29)	0.19 ± 0.01^abcde (53.96)	0.15 ± 0.01^abcd (61.41)

Values are expressed as mean ± SEM (n = 6 rats in each group) and analyzed by one-way ANOVA followed by post hoc Tuckey’s test; ^acompared with 2% tween 80, ^bcompared with 100 mg/kg AF, ^ccompared with 200 mg/kg AF; ^dcompared with 100 mg/kg n-HF;^e100 mg/kg EAF; ; BV = basal volume; Dexa = dexamethasone; 2% tween 80 = negative control; AF, n-HF, and EAF are aqueous, n-hexane, and ethyl acetate fractions of A. mexicana, respectively.