Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Table 7

Effects of solvent fractions of A. mexicana fruits on cotton pellet-induced granuloma in rats.

Treatment group	Mean weight of exudates in mg (mean ± S.E.M) (% inhibition)	Mean weight of granuloma in (mg) (mean ± S.E.M) (% inhibition)
2% Tween 80, 10 ml/kg	124.80 ± 0.64	144.41 ± 1.02
Dexa, 0.5 mg/kg	75.83 ± 1.9^abcde (39.24)	67.27 ± 0.94^abcdef (53.42)
100 mg/kg AF	123.15 ± 0.87 (1.32)	132.27 ± 2.06^a (8.41)
200 mg/kg AF	98.06 ± 2.31^a (21.42)	100.24 ± 2.74^ab (30.58)
400 mg/kg AF	85.36 ± 0.60^abd (31.59)	76.32 ± 0.67^ab (47.15)
100 mg/kg n-HF	101.70 ± 0.58^ab (18.51)	81.46 ± 1.30^ab (43.09)
200 mg/kg n-HF	92.53 ± 1.46^ab (25.86)	78.29 ± 1.11^abc (45.78)
400 mg/kg n-HF	85.79 ± 2.10^abcd (31.25)	70.25 ± 0.95^abcd (51.35)
100 mg/kg EAF	98.92 ± 1.07^ab (20.73)	80.78 ± 1.67^abc (44.06)
200 mg/kg EAF	89.04 ± 2.08^abd (28.65)	75.79 ± 0.76 ^abc (47.52)
400 mg/kg EAF	77.26 ± 2.73^abcde (38.09)	67.19 ± 0.88^abcde (53.47)

Values are expressed as mean ± SEM (n = 6 rats in each group) and analyzed by one-way ANOVA followed by post hoc Tuckey’s test; ^acompared with 2% tween 80, ^bcompared with 100 mg/kg AF, ^ccompared with 200 mg/kg AF; ^dcompared with 100 mg/kg n-HF;^e100 mg/kg EAF; ^fcompared with 200 mg/kg n-HF;; Dexa = dexamethasone; 2% tween 80 = negative control); AF, n-HF, and EAF are aqueous, n-hexane, and ethyl acetate fractions of A. mexicana, respectively.