Ginsenoside Rh4 Inhibits Colorectal Cancer Cell Proliferation by Inducing Ferroptosis via Autophagy Activation

Figure 5

Rh4 promotes the activation of p53 signaling pathway and ubiquitin-mediated proteolysis in HT29 xenograft tumor tissue. (a) Heatmap showing the cluster of differential in Rh4 treatment and tumor control group. Up- and downregulation are represented in red and green, respectively. (b) The volcano plot of differential expression signals in Rh4 treatment and tumor control group. In the enrichment analysis of GO and KEGG pathways, the expression of Rh4 treatment group was more upregulated than that of tumor control group. (c) The bubble map of GO enrichment analyses of differential expressions in HT29 xenograft tumor tissue. The GeneRatio represents the degree of enrichment. The node size shows the number of selected genes, and the color scale represents the padj. (d) The bubble map of KEGG pathway enrichment analyses of differential expressions in HT29 xenograft tumor tissue. The GeneRatio represents the degree of enrichment. The node size shows the number of selected genes, and the color scale represents the padj. n = 3.

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