Review Article

Current Status and Evaluation of Randomized Clinical Trials of Traditional Chinese Medicine in the Treatment of Cardiovascular Diseases

Table 4

Characteristics of included RCTs on chronic heart failure.

ResearcherDiagnostic criteriaSample sizeInterventionFollow-up periodOutcome
ExperimentControlExperimentControl

Jingyuan MaoIschemic heart disease with LVEF ≤45%, NYHA II–IV319319Qishen Yiqi dripping pills + standard treatmentPlacebo + standard treatment6 monthsIncreased 6-minute walking distance, improved the quality of life
Xinli LiChinese guidelines for the diagnosis and management of CHF, LVEF ≤ 40% and a serum NT-proBNP level 450 pg/ml256256Qili Qiangxin capsules + standard treatmentPlacebo + standard treatment12 weeksReduced NT-proBNP level, improved NYHA functional classification, LVEF and 6-min walking distance
Chen WangThe Framingham HF diagnostic criteria + TCM syndrome differentiation138127Shencao Tongmai granule + standard treatmentPlacebo + standard treatment12 weeksImproved NYHA functional classification and LVEF
Shaoxiang XianCHF combined with CAD, NYHA functional classification II–IV + TCM syndrome differentiation120120Shenmai injection + standard treatmentPlacebo + standard treatment7 daysImproved NYHA functional classification, and 6-minute walking distance and TCM syndrome score
Shao-Xiang XianClinical cardiology, 3200 medical
Disease diagnostic Criteria + TCM syndrome differentiation
116112Yangxinkang tablets + standard treatmentPlacebo + standard treatment4 weeksImproved the quality of life and symptoms
Jingui XueACCF/AHA guidelines for the diagnosis and management of heart failure in adults5050Xinmailong injection + standard treatmentPlacebo + standard treatment5 daysReduced BNP, improved NYHA functional classes and LVEF
Ju-Hsin ChengAHA guidelines for the diagnosis and management of heart failure in adults, NYHA functional classification II5050Chan-Chuang QigongBlank control12 weeksImproved the quality of life and 6-minute walking distance