Traditional Chinese Medicine Regulates Th17/Treg Balance in Treating Inflammatory Bowel Disease

Table 2

Interventional effect of Chinese herbal compound on Th17/Treg balance in IBD.

Name	Equilibrium mechanism	Model	References
Gegen Qinlian Decoction	Restored by inhibition of IL-6/JAK2/STAT3 signaling	DSS rat	[83]
Qingchang Wenzhong Formula	Regulated by decreasing the expression of miR-675-5p and targeting and regulating the VDR signaling pathway	DSS rat	[85]
Shaoyao Decoction	Regulated by inhibiting HIF-1α	TNBS rat	[87]
Baitouweng Decoction	Decrease the expression of cytokines associated with Th17 cells differentiation (including IL-6, IL-1β, and TNF-α) and upregulate the expression of IL-10	DSS mice	[89]
Jiedu Huayu Decoction	Decrease IL-17, increase IL-10 and TGF-β, and regulate the expression of RORγt and Foxp3 mRNA	Patients	[90]
Compound Kushen Decoction	Decrease the proportion of Th17 cells and increase the proportion of Treg cells	DSS mice	[91]
Rhubarb Peony Decoction	Decrease the proportion of Th17 cells and increase the proportion of Treg cells	DSS mice	[92]
Bawei Xileisan	Expression of Th17-associated cytokines IL-17 A/F and IL-22 was decreased in a dose-dependent manner	DSS mice	[94]
Yi-Yi-Fu-Zi-Bai-Jiang-San	Decrease the expression of RORγtmRNA and the content of IL-17, increase the expression of Foxp3 mRNA, and increase the content of IL-10	TNBS rat	[96]
Qingchang Huashi Recipe	Downregulate IDO1 expression, RORγt, and related proinflammatory factors and upregulate Foxp3 and related anti-inflammatory factors	TNBS mice	[97]
Huangqin Decoction	Restoration of balance through regulatory effects on Th17 and Treg cytokines and transcription factors	TNBS rat	[98]
Liancao Xieli Capsule	Decrease the expression levels of p-STAT3 and RORγt proteins and increase the expression levels of p-STAT5 and Foxp3 proteins	DSS mice	[99]
Wei Chang An Pill	Increasing the percentage of Treg cells and downregulating the percentage of Th17 cells	DSS mice	[100]
Kaijieling	Inhibit the STAT3 pathway	TNBS rat	[101–103]
Xiaokui Recipe	Promote Treg cells differentiation and generation and inhibit Th17 cells differentiation	TNBS rat	[104]
Ulcerated enema	Increase the number of Treg cells, upregulate IL-10, and reduce the number of Th17 cells	DSS mice	[105]

Abbreviations. Foxp3: forkhead-like protein 3; HIF-1α: hypoxia-inducible factor -1alpha; IL: interleukin; IDO1: indoleamine 2,3-dioxygenase 1; JAK2: Janus kinase-2; miR-675-5pa: microRNA-675-5pa; RORγt: retinoic acid-related orphan receptor gamma t; STAT3: transcription protein 3; TGF; transforming growth factor; VDR: vitamin D receptor; TNF-α: tumor necrosis factor -alpha.