Effect of Auricular Acupressure on Acute Pain in Nursing Home Residents with Mild Dementia: A Single-Blind, Randomized, Sham-Controlled Study

Zhang, Jun-Jun; Yu, Li; Mei, Jun-Hui; Wang, Hong-Xin; Gao, Hai-Xiang; Fu, Ju-Fang; Cheng, Ye; Gao, Lu-Lu; Bu, Lei; Yu, Jian-Qiang; Wang, Carol Chunfeng; Li, Yu-Xiang

doi:https://doi.org/10.1155/2022/6406383

Evidence-Based Complementary and Alternative Medicine

On this page

Abstract Introduction Materials and Methods Discussion Limitations Conclusions Data Availability Ethical Approval Conflicts of Interest Authors’ Contributions Acknowledgments References Copyright Related Articles

Research Article | Open Access

Volume 2022 | Article ID 6406383 | https://doi.org/10.1155/2022/6406383

Effect of Auricular Acupressure on Acute Pain in Nursing Home Residents with Mild Dementia: A Single-Blind, Randomized, Sham-Controlled Study

Jun-Jun Zhang,^1,2Li Yu,¹Jun-Hui Mei,¹Hong-Xin Wang,¹Hai-Xiang Gao,³Ju-Fang Fu,⁴Ye Cheng,⁴Lu-Lu Gao,⁵Lei Bu,⁶Jian-Qiang Yu,⁷Carol Chunfeng Wang,⁸and Yu-Xiang Li²

Academic Editor: Woon-Man Kung

Received06 Oct 2021

Revised29 Dec 2021

Accepted10 Feb 2022

Published10 Mar 2022

Abstract

Introduction. Acute pain is a prevalent problem for dementia residents in nursing homes. A variety of intervention strategies have been applied to address this problem. However, there remains an issue of inadequate pain control. This study aims to explore the analgesic efficacy of auricular acupressure (AA) for dementia residents with acute pain in nursing homes. Methods. A multicenter, single-blind, randomized, and sham-controlled clinical trial was performed in three nursing homes in Yinchuan, China. All of the 206 eligible patients with acute pain were randomly divided into two groups for real AA therapy or sham AA (at sham point stimulation) therapy. The primary outcome was measured with a face pain scale revised (FPS-R) score before the procedure, 5 min after the start of the intervention, and 5 min after finishing the procedure. Secondary outcomes covered three physiological parameters, adverse reactions observed, satisfaction level of caregivers, acceptance of patients, and additional use of analgesics. Results. There was a significant difference in pain scores based on FPS-R between the two groups (). Pain score in the true AA group was 1.84 ± 0.23, compared with 2.22 ± 0.81 in the sham AA group. No adverse events were found during the whole procedure for all patients. The satisfaction level of caregivers and acceptance of patients in the real AA group were significantly higher than those in the sham AA group. Conclusion. This study shows that real AA was an alternative analgesic modality in reducing acute pain in patients with mild dementia.

1. Introduction

It has been estimated that there are over 50 million patients with dementia around the world, and over 20% of them are in China [1, 2]. By 2030, cases of dementia in China are expected to over 16 million at the current rate of growth [2]. As expected, up to 80% of residents living in nursing home settings have a diagnosis of dementia [3].

Pain is the most common complaint of residents with dementia in nursing homes. The prevalence of pain among residents is significantly higher than in other communities, with numerous studies indicating that as many as 40% to 80% of these residents with dementia were affected by pain [4–6]. A study in Europe reported that up to 82.9% of senior citizens with dementia experience pain in the nursing home [7]. Pain is not only an unpleasant subjective experience but also the main culprit of many detrimental consequences. They include neuropsychiatric symptoms, social interaction impairment, poor quality of life, lack of appetite, and other geriatric syndromes and events, including suicide attempts [7–9]. Potentially, the risk of disability increases with pain intensity [9].

These guidelines recommend paracetamol as a first-line approach for dementia patients with communication problems, which aligns with systematic reviews [10–12]. Currently, it is used in nursing homes worldwide. Acute or long-term overdose of paracetamol can contribute to hepatotoxicity, especially for the elderly who are more susceptible to drug-related adverse effects [8]. Patients with dementia are facing more challenges than those without cognitive impairment regarding controlling pain. The amount of analgesics prescribed by the doctor is only one-third of the normal cognitive elderly, which does not have access to the best clinical standard [13]. The use of strong opioids for dementia patients with moderate to severe pain is appropriate in some national guidelines [8, 11], but they receive fewer opioids because medical workers, patients, and family members are concerned about the potential negative side effects [13, 14]. Studies have shown that pain management may be insufﬁcient or inappropriate in nursing home settings [8, 10]. Efforts to explore non-pharmacological therapies to control pain have never stopped. There are also guidelines that emphasize the importance of non-pharmaceutical strategies [15, 16]. And some studies report that non-pharmaceutical measures are effective in controlling pain and reducing opioid use [15, 17]. Therefore, it is important to seek non-drug therapies for treating dementia patients with acute pain. Traditional Chinese medicine, such as auricular acupressure, acupuncture, massage, liniments, ointments, and so on, plays an active important role in the treatment of acute pain. In traditional Chinese medicine (TCM) theory, the ear is where the body’s meridians (main twelve meridians: six of which are yin meridians and six yang) connect and the essential Qi converges. Therefore, stimulating auricular points can activate Qi and blood circulation, dredge the meridians, and then achieve the purpose of analgesia [18].

The use and safety of auricular acupressure (AA) have been well studied in managing acute postoperative pain after surgery, primary dysmenorrhea, and other medical conditions [17, 19, 20]. This study aims to verify the hypothesis that AA can produce analgesic effects on dementia patients with acute pain in nursing homes.

2. Materials and Methods

2.1. Study Design

This study is a multicenter, single-blind, randomized, and sham-controlled clinical trial of AA as described in a study protocol [21]. The trial is performed from April 2018 to March 2020 at old-age care institutions in Yinchuan, China. The study has been approved by Ningxia Medical University Ethics Committee (2018–232). The trial has been registered at the Chinese Clinical Trial Registry (No.: ChiCTR1800019146). Written informed consent was obtained from all subjects and guardians of them in this study.

2.2. Participants

Nursing home residents who were recruited into the study must meet the following standards: 60 years or older, mild dementia (according to the Chinese Mini-Mental State Examination, CMMSE) [22], the score of acute pain ≥4 (based on the face pain scale revised, FPS-R), able to access the multifunctional pulse oxygen monitor, and sign the informed consent for participating. Exclusion criteria included allergic history to adhesive tapes and alcohol, experience with AA before this study, moderate or severe dementia, acute abdomen, medical contraindications (ear inflammation, ulcer, and frostbite), severe heart, brain, liver, kidney, or hematopoietic diseases.

2.3. Treatments

Patients eligible for recruitment were randomly assigned to an intervention or a control group. The intervention group received routine pain management plus real AA therapy (medical adhesive tape with raw Semen Vaccariae), while routine pain management plus sham AA therapy (at sham points stimulation) was applied to the control group. Auricular-plaster therapy was an adhesive tape with a seed in the middle fixed to various auricular points, stimulating the auricular points with your fingers on both ears. There were significant differences in terms of the selected acupoints and function of acupoint combination between the two groups. In this study, Shenmen (TF4), Subcortex (AT4), Adrenal gland (TG2P), and two anatomical regions corresponding to the site of pain were selected to relieve pain in the intervention group. These five points (kidney, CO10; ocuiput, AT3; internal ear, L06; external ear, TG1u, and adrenal gland, TG2P) were selected in the control group. The main effect of these five points was to delay hearing loss. Two anatomical regions were selected by the inverted fetus map [23]. Prior to the intervention, a professionally trained practitioner used an auricular point detector (XS-100A; Guangzhou City Strong Medical Technology Co. Ltd., Guangzhou, China) to find the sensitive points, which are the target acupoints. It is used to probe the corresponding ear area gradually from the periphery to the center or probe the positive reaction points. The pressure should be light, slow, and uniform. Target points would be disinfected using 75% alcohol. Then, adhesive tapes (6 mm × 6 mm) were attached to the selected acupoints on both ears. Then, the practitioner pressed continuously the acupoints for 1 min per point 2 times. The whole intervention lasted for 10 minutes. The optimal pressure was considered as that patient felt localized tingling pain, warm sensation, and/or numbness and within the patient’s tolerance. For the control group, the number and frequency of pressing were the same as the intervention group besides the selection of auricular acupoints. After the intervention, tapes were removed from the ears [24]. Optimal pressure was that patients felt localized tingling pain, warm sensation, and/or numbness and within the patient’s tolerance.

2.4. Binding

All of the 206 patients deemed eligible were randomized into the real AA group or the sham AA group by using a randomization list. Patients were assigned to two groups at 1:1 ratio. The randomization list was generated by an independent statistician with the random number generator in SPSS 22.0 (SPSS Inc., Chicago, IL, USA). And only the project manager and operator had access to it. It was blinded for other researchers (data collectors and administrators, outcome assessors, statisticians, etc.) as well as patients and medical workers to the subject’s sequence number throughout the whole trial. To reduce bias, researchers were not allowed to communicate regarding data collection.

2.5. Sample Size

Prior to the study, we conducted a pilot trial with a sample size of 30 patients in a nursing home in Yinchuan. The change of pain score was the primary outcome. The trial showed that the control group’s mean score was 5.97 ± 1.81, and the intervention group was 4.79 ± 1.96. Therefore, the sample size of the two study groups was 172 subjects (each group 86 cases) with an alpha of 0.05 level (type I error of 0.05, two-tail test) and β = 0.10 (a power of 90%). Considering a 20% dropout rate, we thought that increasing the sample size to 206 subjects was necessary to improve the validity of the study.

2.6. Measurement

Besides the patient’s demographic data (age, gender, nationality, education, and marital state), the site of pain was recorded by data collectors as well. The primary outcome was measured by researchers at baseline (before performing the procedure, T0), 5 min (during the procedure, T1), and 5 min after treatment (postprocedure, T2) with FPS-R. It consisted of six facial expressions sorting pain levels (happy face = no pain and crying face = worst pain, ranging from 0 to 10), which was reliable and valid in older adults with dementia [25]. Secondary outcomes included three physiological parameters (blood pressure, heart rate, and oxygen saturation), any adverse reactions observed, satisfaction level from caregivers, acceptance of patients, and additional use of analgesics. Three physiological parameters were measured at T0, T1, and T2. Other secondary outcomes were recorded at T2. Caregivers’ satisfaction level with this intervention was measured by a five-point scale (from 5 = very satisfied to 1 = very dissatisfied). The researcher assessed patients’ acceptance by asking them if they would like to accept AA therapy once again. The adverse effects during the trial were recorded. Additional use of analgesics was documented during the procedure.

2.7. Statistical Analysis

All quantitative statistical analysis was conducted by SPSS 22.0 statistical software based on the intention-to-treat principle. Continuous data with normal distribution were analyzed by the independent sample t-test and were described as mean (standard deviation) or proportions. The chi-square test was used to analyze the ordinal categorical data. The repeated-measure analysis of variance was selected to describe three physiological parameters (heart rate, blood pressure, and O₂ saturation) and the FPS-R scores. The Mann–Whitney test was used for the non-normal distribution parameters (satisfaction level of caregivers and acceptance of patients). Two-sided value <0.05 was considered statistically significant.

3. Result

A total of 341 potential mild dementia patients with moderate-to-severe acute pain were screened for eligibility during the initial enrollment in three nursing homes in Yinchuan from April 2018 to March 2020, among which 135 dropped out, and 114 of them were further excluded as they did not meet the inclusion criteria. Subsequently, 20 were unwilling to participate in the study, and 1 was excluded owing to adhesive tape allergy. The 206 remaining patients completed the study, of which 103 patients were allocated in the real AA group and 103 in the sham AA group (Figure 1). The demographic and baseline characteristics of patients in the two groups were shown in Table 1. Patients’ characteristics between the real AA group and sham AA group were well balanced in terms of age (82 (80–83) and 84 (83–85), ), gender (147 males, ), nationality (), education background (), marital state (), occupation (), the use of analgesic (), and location of the pain (). There were no statistically significant differences ().

Changes in pain scores based on the FPS-R for each group were summarized in Table 2 and Figure 2. There was a significant difference between the two groups (), but there was no statistical significance at T0. Pain scores in episodes treated with true AA decreased from 5.19 ± 0.81 (at T0) to 2.51 ± 0.72 (at T1) and 1.84 ± 0.23 (T2). For patients treated with sham AA, pain scores ranged 5.33 ± 0.91 from 5.31 ± 0.52 to 4.22 ± 0.81 at T0, T1, and T2, respectively.

The three physiological parameters were presented in Table 3. There was no difference between the two groups (). As summarized in Table 4, analysis of the additional use of analgesics found no significant difference between the two groups. Table 3 indicated that there was 3 (2.9%) patients having an additional use of painkillers in the sham AA group at T2, while it did not occur in the real AA group. No adverse events were found during the whole procedure between the two groups. The satisfaction level of caregivers in the sham AA group was significantly lower than the real AA group (Z = −11.653, ; Table 5). This was also the case with the acceptance of patients for AA therapy (see Table 5). The acceptance of patients in the intervention group was notably higher than that of the control group (Z = −8.088, ).

4. Discussion

In this present study, the real AA group has better results than the sham AA group in reducing pain intensity in dementia patients with acute pain. Furthermore, there are no side effects and complications associated with AA therapy.

Numerous studies have identified the safety and efficacy of AA therapy. The results of this study show that the use of AA is safe and effective for relieving acute pain, which was consistent with existing studies [17, 19]. A systematic review indicates that there is a significant difference in the AA group compared with the control group on acute postoperative pain after surgery relief [19]. Moreover, all of the 26 studies with 1,682 participants incorporated in the review did not observe adverse events, which recommends that AA be applied to control acute postoperative pain. In another study, Cha et al. showed that AA therapy is effective for alleviating primary dysmenorrhea of female high school students in South Korea (t = 32.187, ) [17]. There is a study focusing on AA for decreasing the level of pain in elder patients with acute hip fractures. As a result, the patients in the true AA group have lower pain scores (F = 28, ) than patients in the sham AA group, which demonstrates that AA is effective in reducing pain [26].

Statistical analysis of this study demonstrates that there is no significant difference among the three vital signs, including blood pressure, heart rate, and oxygen saturation. A randomized controlled trial evaluated the effect of the intervention group (AA group) on physiological indicators of variability in hypertensive patients compared with the control group. No differences are shown between the two groups in blood pressure and heart rate () [27]. This study also displays that the satisfaction levels from caregivers and acceptance from participants in the AA group are higher than those in the control group. Other studies on AA have illustrated a similar result. Yeh et al. designed a feasibility study that AA is described as an adjunct analgesic to manage pain in cancer patients. The study found that AA was highly accepted by patients with cancer-related pain for AA as an adjunct analgesic [28]. Another randomized double-blinded study reported that patients in the real AA group had higher satisfaction than those in the sham AA group [17].

The Declaration of Montreal claims that access to pain management is a fundamental human right and the obligation of medical providers offering to a patient [29]. However, there are many studies focusing on the interventions in acute pain management, but a dearth of studies highlight the older patients. Even fewer studies have focused on acute pain management in nursing home residents with dementia. Abundant studies have reflected that optimal acute pain management in elderly patients with dementia remains an elusive goal [4, 8, 10, 13]. For dementia patients in the nursing home, it is recommended that a first-line treatment modality for pain is pharmacological intervention [11]. Considering the high-risk group of patients with senile dementia, drug safety (adverse effects and abuse potential) is highly concerned. Therefore, there is a need to explore a therapy that has the characteristics of non-invasive, has fewer side effects, and is effective for this population.

From the ancient record (The Yellow Emperor’s Classic of Internal Medicine written in Chinese) to nowadays days, auricular therapy as a complementary and alternative technology has been employed for approximately 2,500 years. AA is one of the common methods of auricular therapy. And it was more widely applied for controlling various types of pain since the advent of Nogier’s somatotopic maps. The ear is where 12 meridians are directly or indirectly connected. Stimulating it can achieve the purpose of qi-blood circulation, dredge meridians, and then analgesia according to traditional Chinese medicine (TCM) theory [18]. The mechanism of AA has a close relationship with the autonomic nervous system. The study has revealed that the analgesic effects of AA are caused by activation of the descending pain inhibitory pathways in the brain stem and thus ascending pain pathway inhibition. The application of AA activates the descending pain suppressing pathway along the spinal cord dorsal, thereby relieving pain. Hence, deep brain stimulation can exert a pain-relieving potency via inhibiting the dorsal lateral funiculus of the spinal cord [18]. In addition, benign stimuli generated by AA make the sympathetic nerve and parasympathetic nerve send impulses to the central nervous systems. After the integration of the system, the positive factors inside the human body are mobilized to raise the pain threshold [18, 30].

Many studies [18, 31] have shown that “shenmen” has the effect of stimulating and inhibiting the cerebral cortex. It was the main point for pain relief, suitable for various types of pain. “Subcortical” had the effect of sedation, analgesia, for clinical ear analgesia commonly used points. The function of the “adrenal gland” was to regulate the yin and yang of the human body and has analgesic and heat-clearing effects. The combination of the three acupoints strengthens the analgesic effect. In this study, they were elected as the primary acupoints for pain relief in the intervention group. However, their combination had no analgesic effect in the controlled group. So true AA worked more than sham AA.

Overall, the AA method has the undeniable advantages of safety, non-invasiveness (with less chance of infection), low cost, and even self-administration. Once AA tape is applied, it can stay in the auricular point for a long time. The patient can use his finger to gently press to stimulate the auricular points. AA seems to be a promising adjunct analgesic treatment for pain relief in nursing homes.

5. Limitations

The present study was designed to be single-blinded and performed in a single regional municipality. The pain level in the following hours after the procedure was not recorded in the study to evaluate the long-term effect (analgesic effect and safety). Furthermore, the study did not recruit different ages of patients, and our findings cannot be generalized to other patient settings. Thus, multiple regions and large-sample studies are warranted to determine the analgesic effect of AA therapy.

6. Conclusions

This study shows that real AA was an alternative analgesic modality in reducing acute pain in patients with mild dementia. There are few side effects during the study period. Medical providers may take the AA method into consideration for alleviating acute pain in nursing home residents with dementia, especially in low-resource settings.

Data Availability

All data generated or analyzed during this study are included in this article. Further enquiries are available on reasonable request to the corresponding author.

Ethical Approval

The Ningxia Medical University Ethics Committee (2018–232) has given its given official approval for the study. Participants have signed the conformed consent after the researchers provided them with detailed information regarding the study process and the right they have.

Conflicts of Interest

The authors have no conflicts of interest to declare.

Authors’ Contributions

J-J Z and C-C W drafted the manuscript and contributed to the conception, design, and critical revision of the manuscript in collaboration with L Y, J-H M, H-X W, and J-Q Y. J-J Z, J-F F, Y C, and L B contributed to the development of the intervention and the critical revision of the manuscript. Statistical analyses were performed by H-X G and L-L G. All authors read and approved the final manuscript. Y-X L is the principal investigator of the study. J-J Z, L Y, J-H M, and H-X W contributed equally to the study.

Acknowledgments

The support from staff and participation of the residents in three nursing homes in Yinchuan is appreciatively acknowledged. The authors would like to thank the Ningxia Medical University and Shenzhen University General Hospital for their support. A single-blind, randomized, and sham-controlled clinical trial of AA was described in a study protocol that is being published as “preprint” in “research square.” This work was financially supported by grants from the Chinese National Major Project for New Drug Innovation (2019ZX09201002003), National Natural Science Foundation of China (82030076, 82070161, 81970151, 81670162, and 81870134), Shenzhen Key Laboratory Foundation (ZDSYS20200811143757022), and Shenzhen Science and Technology Foundation (JCYJ20190808163601776 and JCYJ20200109113810154).

References

Alzheimer’s Disease International, “Dementia facts and figures,” 2021, https://www.alzint.org/about/dementia-facts-figures.
View at: Google Scholar
L. Jia, M. Quan, Y. Fu et al., “Dementia in China: epidemiology, clinical management, and research advances,” The Lancet Neurology, vol. 19, no. 1, pp. 81–92, 2020.
View at: Google Scholar
M. S. Petersen, “Assessing the prevalence of undetected possible dementia in faroese homes,” Dementia and Geriatric Cognitive Disorders, vol. 48, no. 1-2, pp. 30–38, 2019.
View at: Publisher Site | Google Scholar
T. F. Habiger, W. P. Achterberg, E. Flo-Groeneboom, J. Mannseth, and B. S. Husebo, “Managing pain and psychosis symptoms in nursing home patients: results from a cluster-randomized controlled trial (COSMOS),” Journal of the American Medical Directors Association, vol. 22, no. 8, pp. 1692–1698, 2021.
View at: Google Scholar
I. Babicova, A. Cross, D. Forman, J. Hughes, and K. Hoti, “Evaluation of the Psychometric properties of PainChek® in UK aged care residents with advanced dementia,” Biomedical ChromatographyGeriatrics, vol. 21, no. 1, p. 337, 2021.
View at: Publisher Site | Google Scholar
A. Minaya‐Freire, M. Subirana‐Casacuberta, E. Puigoriol‐Juvanteny, and A. Ramon‐Aribau, “Pain management nursing practice assessment in older adults with dementia,” Nursing Open, vol. 8, no. 6, pp. 3349–3357, 2021.
View at: Publisher Site | Google Scholar
Y. J. Jenny Wei, C. Chen, R. B. Fillingim et al., “Uncontrolled pain and risk for depression and behavioral symptoms in residents with dementia,” Journal of the American Medical Director Association, vol. 22, no. 10, pp. 2079–2086, 2021.
View at: Publisher Site | Google Scholar
C. Ando, Y. Kanno, O. Uchida, E. Nashiki, N. Kosuge, and A. Ogawa, “Pain management in community-dwelling older adults with moderate-to-severe dementia,” International Journal of Palliative Nursing, vol. 27, no. 3, pp. 158–166, 2021.
View at: Publisher Site | Google Scholar
K. M. Blytt, E. Flo-Groeneboom, A. Erdal, B. Bjorvatn, and B. S. Husebo, “Sleep and its association with pain and depression in nursing home patients with advanced dementia-a cross-sectional study,” Frontiers in Psychology, vol. 12, Article ID 633959, 2021.
View at: Publisher Site | Google Scholar
L. Bullock, J. Bedson, J. L. Jordan, B. Bartlam, C. A. Chew‐Graham, and P. Campbell, “Pain assessment and pain treatment for community‐dwelling people with dementia: a systematic review and narrative synthesis,” International Journal of Geriatric Psychiatry, vol. 34, no. 6, pp. 807–821, 2019.
View at: Publisher Site | Google Scholar
K. S. Frederiksen, C. Cooper, G. B. Frisoni et al., “A European academy of neurology guideline on medical management issues in dementia,” European Journal of Neurology, vol. 27, no. 10, pp. 1805–1820, 2020.
View at: Publisher Site | Google Scholar
Y. I. P. Tsai, G. Browne, and K. J. Inder, “The effectiveness of interventions to improve pain assessment and management in people living with dementia: a systematic review and meta‐analyses,” Journal of Advanced Nursing, vol. 77, no. 3, pp. 1127–1140, 2021.
View at: Publisher Site | Google Scholar
F. F. La, V. Vickerstaff, C. Cooper, G. Livingston, P. Stone, and E. L. Sampson, “Factors influencing prescription and administration of analgesic medication: a longitudinal study of people with dementia living in care homes,” International Journal of Geriatric Psychiatry, vol. 14, pp. 1–8, 2021.
View at: Publisher Site | Google Scholar
T. Jonsdottir and E. C. Gunnarsson, “Understanding nurses’ knowledge and attitudes toward pain assessment in dementia: a literature review,” Pain Management Nursing, vol. 22, no. 3, pp. 281–292, 2021.
View at: Publisher Site | Google Scholar
J. M. Ellis, Y. Wells, and J. S. M. Ong, “Non-pharmacological approaches to pain management in residential aged care: a pre-post-test study,” Clinical Gerontologist, vol. 42, no. 3, pp. 286–296, 2019.
View at: Publisher Site | Google Scholar
A. R. Qureshi, M. K. Jamal, E. Rahman et al., “Non‐pharmacological therapies for pain management in Parkinson’s disease: a systematic review,” Acta Neurologica Scandinavica, vol. 144, no. 2, pp. 115–131, 2021.
View at: Publisher Site | Google Scholar
N. H. Cha and S. R. Sok, “Effects of auricular acupressure therapy on primary dysmenorrhea for female high school students in South Korea,” Journal of Nursing Scholarship, vol. 48, no. 5, pp. 508–516, 2016.
View at: Publisher Site | Google Scholar
H. Pu-Wei, H. Hsin-Cheng, L. Yi-Wen, T. Nou-Ying, C. Chin-Yi, and H. Ching-Liang, “The history, mechanism, and clinical application of auricular therapy in traditional Chinese medicine,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 495684, 13 pages, 2015.
View at: Publisher Site | Google Scholar
Q. Zhong, D. Wang, Y.-M. Bai, S.-Z. Du, Y.-L. Song, and J. Zhu, “Effectiveness of auricular acupressure for acute postoperative pain after surgery: a systematic review and meta-analysis,” Chinese Journal of Integrative Medicine, vol. 25, no. 3, pp. 225–232, 2019.
View at: Publisher Site | Google Scholar
M. Liu, Y. Tong, L. Chai et al., “Effects of auricular point acupressure on pain relief: a systematic review,” Pain Management Nursing, vol. 22, no. 3, pp. 268–280, 2021.
View at: Publisher Site | Google Scholar
https://assets.researchsquare.com/files/rs-3252/v2/988a85e0-9b2e-4596-91da-94f6f4704f94.pdf?c=1631888346.
X. Fu, W. Yu, M. Ke et al., “Chinese version of the baylor profound mental status examination: a brief staging measure for patients with severe Alzheimer’s disease,” Prevention of Alzheimer Disease, vol. 18, pp. 175–180, 2021.
View at: Google Scholar
G. Litscher, T. Yannacopoulos, and P. Kreisl, “Nogier reflex: physiological and experimental results in auricular medicine-a new hypothesis,” Medicines (Basel), vol. 5, no. 4, p. 132, 2018.
View at: Publisher Site | Google Scholar
T. Yuhua, Z. Ye, H. Tian, M. Yueshen, C. Wang, and W. Yandong, “Efficacy and safety of auricular point acupressure treatment for gastrointestinal dysfunction after laparoscopic cholecystectomy: study protocol for a randomized controlled trial,” Trials, vol. 17, p. 280, 2016.
View at: Google Scholar
T. Hadjistavropoulos, K. Herr, K. M. Prkachin et al., “Pain assessment in elderly adults with dementia,” The Lancet Neurology, vol. 13, no. 12, pp. 1216–1227, 2014.
View at: Publisher Site | Google Scholar
R. Barker, A. Kober, K. Hoerauf et al., “Out-of-hospital auricular acupressure in elder patients with hip fracture: a randomized double-blinded trial,” Academic Emergency Medicine, vol. 13, no. 1, pp. 19–23, 2006.
View at: Publisher Site | Google Scholar
M.-L. Yeh, Y.-C. Chang, Y.-Y. Huang, and T.-Y. Lee, “A randomized controlled trial of auricular acupressure in heart rate variability and quality of life for hypertension,” Complementary Therapies in Medicine, vol. 23, no. 2, pp. 200–209, 2015.
View at: Publisher Site | Google Scholar
C. H. Yeh, L.-C. Chien, Y. C. Chiang, D. Ren, and L. K.-P. Suen, “Auricular point acupressure as an adjunct analgesic treatment for cancer patients: a feasibility study,” Pain Management Nursing, vol. 16, no. 3, pp. 285–293, 2015.
View at: Publisher Site | Google Scholar
M. J. Cousins and M. E. Lynch, “The Declaration Montreal: access to pain management is a fundamental human right,” Pain, vol. 152, no. 12, pp. 2673-2674, 2011.
View at: Publisher Site | Google Scholar
A. Santoro, S. L. Nori, L. Lorusso, C. Secondulfo, M. Monda, and A. Viggiano, “Auricular acupressure can modulate pain threshold,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 457390, 7 pages, 2015.
View at: Publisher Site | Google Scholar
L.-N. Dong, The Effects of Auricular-Plaster Therapy on the Pain and Related Serum Indexes after Cesarean Section, Zhejiang University of Traditional Chinese Medicine, Hangzhou, China, 2014.

Copyright

Copyright © 2022 Jun-Jun Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PDF Download Citation

Download other formats

Order printed copies

Views

546

Downloads

663

Citations