Paeoniflorin Enhances the Sensitivity of ER-Positive Breast Cancer Cells to Tamoxifen through Promoting Sirtuin 4

<div>Deletion of SIRT4 increases paeoniflorin-enhanced tamoxifen-induced ER-positive breast cancer cell apoptosis. 48 hours after transfecting with si-SIRT4, T47D and MCF-7 cells were treated with or without PF (60 <i>μ</i>M) or TAM (8 <i>μ</i>M for T47D and 16 <i>μ</i>M for MCF-7) for 48 hours, and the cell viability was determined using the CCK8 assay kit. 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22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,55.606,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.846,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> between two groups. PF = paeoniflorin; TAM = tamoxifen.</div>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Paeoniflorin Enhances the Sensitivity of ER-Positive Breast Cancer Cells to Tamoxifen through Promoting Sirtuin 4 