Research Article
Paeoniflorin Enhances the Sensitivity of ER-Positive Breast Cancer Cells to Tamoxifen through Promoting Sirtuin 4
Figure 7
Deletion of SIRT4 increases the activation of STAT3 in ER-positive breast cancer cells. 48 hours after transfecting with si-SIRT4, T47D and MCF-7 cells were treated with or without PF (60 μM) or TAM (8 μM for T47D and 16 μM for MCF-7) for 48 hours, and we harvested cells to detect the expression of c-myc, STAT3, and p-stat3 protein expression using western blot. Data were expressed as mean ± SD with 3 independent repetitions. ns and between two groups. PF = paeoniflorin; TAM = tamoxifen.
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