Research Article

Herbal Granules of Heat-Clearing and Detoxifying for Children with Mild Hand, Foot, and Mouth Disease: A Bayesian Network Meta-Analysis

Table 1

Results of direct pairwise meta-analysis for all outcomes.

ComparisonsWMD (95% CI)RR (95% CI)
ABCDEFGH

BRGs vs NM−1.06 (−1.24, −0.88)−1.48 (−1.74, −1.22)−1.71 (−2.62, −0.80)−0.36 (−0.81, 0.08)−1.79 (−2.11, −1.47)1.36 (1.10, 1.70)
EHGs vs NM−0.81 (−1.82, 0.20)−1.25 (−2.03, −0.47)1.36 (1.14, 1.63)1.00 (0.15, 6.82)
FTGs vs NM−0.60 (−0.86, −0.34)−0.67 (−0.93, −0.41)1.82 (1.36, 2.43)
HXGs vs NM−1.39 (−1.88, −0.90)−2.56 (−3.13, −1.99)−1.23 (−1.75, −0.71)−2.17 (−2.65, −1.69)1.24 (1.02, 1.52)
JBGs vs NM−1.29 (−1.60, −0.98)
JLHGs vs NM−1.12 (−1.23, −1.01)−1.10 (−1.25, −0.95)−2.54 (−3.40, −1.68)−1.37 (-2.01, -0.73)−1.45 (−1.71, −1.20)1.12 (1.03, 1.23)0.73 (0.30, 1.77)
KangGs vs NM−1.36 (−1.78, −0.94)−0.66 (−1.39, 0.06)−0.96 (−1.31, −0.61)−1.95 (−2.23, −1.67)−1.31 (−2.23, −0.39)−1.00 (−2.56, 0.56)1.10 (0.96, 1.26)1.11 (0.49, 2.54)
KouGs vs NM−1.69 (−2.37, −1.02)−1.25 (−1.54, −0.96)−2.53 (−2.73, −2.33)−3.13 (−3.37, −2.89)1.18 (0.96, 1.45)2.50 (0.50, 12.51)
LQGs vs NM−0.76 (−1.01, −0.52)−1.12 (−1.27, −0.97)−1.20 (−2.01, −0.39)−1.24 (−1.47, −1.00)−0.83 (−0.96, −0.70)−1.91 (−2.05, −1.77)1.19 (1.11, 1.28)0.51 (0.19, 1.38)
QGs vs NM−1.00 (−1.37, −0.63)−1.12 (−1.63, −0.61)−1.25 (−1.58, −0.92)−1.43 (−2.08, −0.78)−1.19 (−2.77, 0.39)−1.48 (−2.08, −0.88)1.16 (1.01, 1.32)
RGs vs NM−0.85 (−1.22, −0.48)−1.80 (−2.66, −0.94)1.12 (1.00, 1.25)
SGs vs NM−1.24 (−1.76, −0.72)−2.57 (−3.13, −2.01)−1.53 (−1.84, −1.22)1.34 (1.09, 1.63)3.00 (0.13, 71.92)
XCTGs vs NM−0.86 (−2.42, 0.69)−1.23 (−2.70, −0.24)−1.10 (−1.37, −0.83)1.54 (0.87, 2.73)
XCQGs vs NM−1.77 (−2.21, −1.32)−2.45 (−3.45, −1.45)−2.23 (−2.78, −1.69)−2.14 (−2.36, −1.92)−2.03 (−2.43, −1.64)−2.45 (−3.12, −1.78)1.17 (1.12, 1.22)0.52 (0.21, 1.30)
XJGs vs NM−1.10 (−1.26, −0.94)−2.80 (−2.92, −2.68)1.18 (0.98, 1.43)0.81 (0.27, 2.47)
XRGs vs NM−2.20 (−2.43, −1.97)−2.39 (−2.80, −1.97)−2.12 (−2.47, −1.77)1.23 (1.11, 1.38)
YNGs vs NM−2.05 (−2.24, −1.86)−3.13 (−3.51, −2.75)1.71 (0.16, 17.98)
HGs-HD vs NM−1.32 (−1.63, −1.01)−1.82 (−2.49, −1.14)−1.72 (−1.98, −1.47)−1.71 (−2.08, −1.34)−1.26 (−1.65, −0.87)−1.98 (−2.41, −1.56)1.20 (1.16, 1.24)0.82 (0.56, 1.20)

WMD, weighted mean difference; 95% CI, 95% confidence interval; RR, relative risk; A, fever clearance time; B, disappearance/scabbing time of rash; C, hospitalization/healing/treatment time; D, disappearance/scabbing time of vesicles; E, improvement time in appetite; F, disappearance/healing time of ulcers; G, total effectiveness rate; H, adverse effect rate; HGs-HD, herbal granules of heat-clearing and detoxifying; NM, no medication; BRGs, Bairui granules; EHGs, Ertong Huichun granules; FTGs, Fangfeng Tongsheng granules; HXGs, Houerhuan xiaoyan granules; JLHGs, Jinlianhua granules; JBGs, Jinye Baidu granules; KangGs, Kanggan granules; KouGs, Kouyanqing granules; LQGs, Lianhua Qingwen granules; QGs, Qingkailing granules; RGs, Reduping granules; SGs, Shanlameiye granules; XCTGs, Xiao’er Chaigui Tuire granules; XCQGs, Xiao’er Chiqiao Qingre granules; XJGs, Xiao’er Jinqiao granules; XRGs, Xiao’er Resuqing granules; YNGs, Yanning granules. The results with statistical significance were marked as bold font; “—” denotes “not included.”