Antidiarrheal Effect of 80% Methanol Extract and Fractions of the Leaves of Ocimum lamiifolium in Swiss Albino Mice

Table 2

Effects of the crude extract and fractions of the leaves of O. lamiifolium on castor oil-induced diarrhea model in mice.

Treatment	Onset of diarrhea (min)	Total no. of feces	Total no. of wet feces	Weight of fresh feces ()	Fluid content of feces ()	% Inhibition of weight	% Inhibition of defecation	% Inhibition of diarrhea
NC	57.00 ± 4.57	5.17 ± 0.87	3.67 ± 0.88	0.71 ± 0.93	0.55 ± 0.10	—	—	—
PC	148.33 ± 20.40^a3	2.50 ± 0.43^a1	1.17 ± 0.31^a1	0.12 ± 0.02^a2	0.03 ± 0.00^a3	83.10	51.64	68.12
CE 100	77.83 ± 3.97^b3	4.33 ± 0.56	2.83 ± 0.60	0.49 ± 0.10	0.17 ± 0.07^a3	30.99	16.25	22.89
CE 200	84.67 ± 6.47^b2	4.00 ± 0.52	2.33 ± 0.49	0.39 ± 0.07	0.14 ± 0.04^a3	45.07	22.63	36.51
CE 400	107.67 ± 10.61^a1	3.00 ± 0.26	1.33 ± 0.21^a1	0.22 ± 0.04^a1	0.07 ± 0.01^a3	69.01	41.97	63.76
BF 100	73.67 ± 3.41^b3	4.50 ± 0.43	3.17 ± 0.40	0.51 ± 0.09^b1	0.27 ± 0.07	28.17	12.96	13.62
BF 200	79.50 ± 4.46^b3	4.00 ± 0.45	2.83 ± 0.40	0.38 ± 0.05	0.21 ± 0.03	46.48	22.63	22.89
BF 400	108.33 ± 6.32^a1	3.33 ± 0.49	2.00 ± 0.45	0.32 ± 0.07	0.19 ± 0.04	54.93	35.59	45.50
DF 100	69.17 ± 3.44^b3	5.00 ± 0.26^b1	3.33 ± 0.21^b1	0.51 ± 0.09^b1	0.29 ± 0.06^b1	28.17	3.29	9.26
DF 200	75.17 ± 3.82^b3	4.33 ± 0.42	3.00 ± 0.37	0.39 ± 0.06	0.24 ± 0.03	45.07	16.25	18.26
DF 400	103.83 ± 5.74^a1,b1	3.50 ± 0.56	2.17 ± 0.48	0.34 ± 0.07	0.21 ± 0.03	52.11	32.30	40.87
NC	56.50 ± 3.52	5.00 ± 0.37	3.50 ± 0.43	0.68 ± 0.05	0.54 ± 0.05	—	—	—
PC	150.00 ± 5.09^a3	2.17 ± 0.31^a3	1.00 ± 0.26^a3	0.10 ± 0.01^a3	0.02 ± 0.00^a3	85.29	56.60	71.43
HF 100	80.50 ± 4.24^a1,b3	3.33 ± 0.42^a1	2.00 ± 0.37^a1	0.54 ± 0.07^b3	0.24 ± 0.03^a3,b3	20.59	33.40	42.86
HF 200	87.83 ± 3.19^a2,b3,e1	2.83 ± 0.31^a2	1.50 ± 0.22^a2	0.47 ± 0.07^b2	0.11 ± 0.01^a3,c1	30.88	43.40	57.14
HF 400	112.33 ± 8.73^a3,b3,c2	2.33 ± 0.21^a3	1.33 ± 0.21^a3	0.24 ± 0.06^a3,c2	0.06 ± 0.01^a3,c2	64.71	53.40	62.00

NC = negative control (dissolved in distilled water), PC = positive control (dissolved in distilled water), CE = crude extract, BF = n-butanol fraction, DF = distilled water fraction, NC = negative control (dissolved in 2% tween-80), PC = positive control (dissolved in tween-80), HF = n-hexane fraction,^a compared to negative control,^b compared to positive control,^c compared to 100,^d compared to 200,^e compared to 400,¹,²,³.