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Study | Age | Sample size (T; C) | Type of oncology treatment | Oral mucositis assessment tool | Intervention | Control | Outcomes |
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Abdulrhman, 2012 | Mean 6.9 | 60 (30; 30) | Methotrexate, 2 g/m2, every two weeks | National Cancer Institute Common Toxicity Criteria | Trifolium alexandrinum honey, 0.5 g/kg, 3 times daily | Benzocaine 7.5% gel, 3 times daily | Recovery time |
Bulut, 2016 | 6–17 | 76 (39; 37) | Methotrexate treatment | WHO Mucositis Assessment Scale | Wildflower honey, 1 g/kg daily | Routine mouth care | Recovery time, mucositis severity |
Jaouni, 2017 | Mean 8 | 40 (20; 20) | Radio/chemotherapy | WHO Mucositis Assessment Scale | Local commercial Saudi honey, 3 times daily | Lidocaine gel | Recovery time, mucositis severity, body weight, aerobic, bacterial, and Candida |
Mishra, 2017 | 5–19 | 40 (20; 20) | 5-F uracil or methotrexate treatment | WHO Mucositis Assessment Scale | Ice cubes made of honey, 5 minutes before chemotherapy | Plain ice cubes | Mucositis severity |
Singh, 2019 | Mean 8.7 | 100 (50; 50) | Chemotherapy | WHO Mucositis Assessment Scale | Commercially available marketed honey, 1–2 ml,4 times daily | Benzalkonium and lignocaine gel | Recovery time, mucositis severity |
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