Effect of Honey on Pediatric Radio/Chemotherapy-Induced Oral Mucositis (R/CIOM): A Systematic Review and Meta-Analysis

Table 2

The characteristics of included studies.

Study	Age	Sample size (T; C)	Type of oncology treatment	Oral mucositis assessment tool	Intervention	Control	Outcomes
Abdulrhman, 2012	Mean 6.9	60 (30; 30)	Methotrexate, 2 g/m^2, every two weeks	National Cancer Institute Common Toxicity Criteria	Trifolium alexandrinum honey, 0.5 g/kg, 3 times daily	Benzocaine 7.5% gel, 3 times daily	Recovery time
Bulut, 2016	6–17	76 (39; 37)	Methotrexate treatment	WHO Mucositis Assessment Scale	Wildflower honey, 1 g/kg daily	Routine mouth care	Recovery time, mucositis severity
Jaouni, 2017	Mean 8	40 (20; 20)	Radio/chemotherapy	WHO Mucositis Assessment Scale	Local commercial Saudi honey, 3 times daily	Lidocaine gel	Recovery time, mucositis severity, body weight, aerobic, bacterial, and Candida
Mishra, 2017	5–19	40 (20; 20)	5-F uracil or methotrexate treatment	WHO Mucositis Assessment Scale	Ice cubes made of honey, 5 minutes before chemotherapy	Plain ice cubes	Mucositis severity
Singh, 2019	Mean 8.7	100 (50; 50)	Chemotherapy	WHO Mucositis Assessment Scale	Commercially available marketed honey, 1–2 ml,4 times daily	Benzalkonium and lignocaine gel	Recovery time, mucositis severity