Evidence-Based Complementary and Alternative Medicine

Research Article

Elaborate the Mechanism of Ancient Classic Prescriptions (Erzhi Formula) in Reversing GIOP by Network Pharmacology Coupled with Zebrafish Verification

Table 1

Chemical components corresponding to gene targets of EZF.
SourceChemical componentsGene targets
FLLLuteolinIL10, RB1, JUN, TOP1, ICAM1, IL2, TYR, IFNG, IL4, INSR, MET
FLLApigeninF7, Bcl-2, PLAU, RB1, JUN, ODC1, IGF1R, ICAM1, IL2, IFNG, IL4, INSR, ALPI
FLLAlpha-humuleneREN
FLLQuercetinF7, Bcl-2, PLAU, IL10, EGF, RB1, JUN, ELK1, ODC1, TOP1, STAT1, CYP1A2, F3, CYP1A1, ICAM1, VCAM1, NOS3, IL2, CYP1B1, PLAT, IFNG, MPO, INSR, IRF1
FLLGeraniolHMGCR
FLLHydroxytyrosolPLAU, STAT1, IRF1
FLLCaffeic acidPLAU, CYP1A1
FLLEugenolPLAU, CYP1A1, CYP1B1
FLLOleanolic acidICAM1
FLLBeta-sitosterolBcl-2, JUN
FLLDaidzeinJUN, NOS3, LDLR, CAT, IGF1R, STAT1, ICAM1, APOB, VCAM1, NOS3, ECE1, IL4, GH1, GHR
FLLKaempferolNOS3, F7, Bcl-2, JUN, STAT1, CYP1A2, CYP1A1, ICAM1, VCAM1, CYP1B1, INSR
FLLUrsolic acidPLAU, Bcl-2, JUN, ICAM1, CREB1, NOS3
FLLDBPGSK-3β
FLLSalidrosideBcl-2
FLLTaxifolinICAM1, APOB
FLLLucidumoside D_qt (灵芝苷)NOS3, GSK-3β
FLLOleoside dimethyl ester_qt (油苷二甲酯)NOS3
FLLSpecnuezhenideIL2, TYR
EPAcacetinNOS3, Bcl-2
EP3′-O-Methylorobol (3′-O-甲酚)GSK-3β, NOS3
EPPratensein (红三叶草素)NOS3, GSK-3β
EPDemethyl wedelolactone (去甲基蟛蜞菊内酯)GSK-3β
EPWedelolactone (蟛蜞菊内酯)GSK-3β