Crocus sativus L. Stigmas, Tepals, and Leaves Ameliorate Gentamicin-Induced Renal Toxicity: A Biochemical and Histopathological Study

Figure 1

Effect of extracts from stigmas (50 mg/kg), tepals (250 mg/kg), and leaves (250 mg/kg) of C. sativus on histological changes of the kidney ((a), (b), (c), (d), and (e)) in gentamicin-intoxicated rats. Histological sections of the kidney tissue (stained with hematoxylin and eosin) were taken from the normal group (a), the gentamicin + distilled water group (b), the gentamicin + STG group (c), the gentamicin + TPL group (d), the and gentamicin + LV group (e). Glomerular degeneration (orange arrow), necrosis at Bowmen’s capsule (gray arrow), distinction of Bowman’s space (red arrow), mononuclear cell infiltration (black arrow), renal tubule desquamation (brown arrow), renal tubule atrophy (blue arrow), and renal tubule dilatation (green arrow).

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