Vasorelaxant and Antioxidant Effects of Aframomum pruinosum Gagnep. (Zingiberaceae) Seed Extracts May Mediate Their Cardioprotective Activity against Isoproterenol-Induced Myocardial Infarction
Table 2
The aqueous (AE) and ethanolic extracts (EE) from Aframomum pruinosum seeds improved the redox status in the heart of rats subjected to isoproterenol (ISO) induced myocardial infarction.
Experimental groups
SOD (U/mg protein)
CAT (U/mg protein)
MDA (nmole/g tissue)
GSH (nmole/g tissue)
Naive
19.20 ± 2.07
13.67 ± 1.43
10.90 ± 2.00
981.90 ± 83.37
ISO
8.07 ± 0.92
8.62 ± 0.66
24.31 ± 0.92
396.80 ± 26.24
Prop + ISO
44.97 ± 8.98
49.53 ± 9.19
4.17 ± 0.75
844.10 ± 94.94
AE 75 + ISO
15.12 ± 1.28
12.46 ± 0.91
4.27 ± 0.56
1204.00 ± 103.40
AE 150 + ISO
28.90 ± 7.82
19.08 ± 4.04
10.52 ± 2.92
800.20 ± 53.26
EE 75 + ISO
119.50 ± 30.93
107.00 ± 18.86
9.29 ± 2.46
647.80 ± 89.23
EE 150 + ISO
42.02 ± 12.32
35.49 ± 7.99
6.55 ± 1.87
737.30 ± 37.37
Data are expressed as mean ± SEM (n = 5–6). ; statistically different compared to naive. ;; statistically different compared to ISO. Numbers refer to the dose in mg/kg.