Research Article

Investigating the Molecular Mechanism of Quercetin Protecting against Podocyte Injury to Attenuate Diabetic Nephropathy through Network Pharmacology, MicroarrayData Analysis, and Molecular Docking

Table 1

21 candidate targets with a degree greater than average.

TargetUniprot IDDescriptionDegree

TNFP01375Tumor necrosis factor34
VEGFAP15692Vascular endothelial growth factor33
AKT1P31749AKT serine/threonine kinase 131
TP53P04637Tumor protein p5329
PTGS2P35354Prostaglandin G/H synthase 228
CXCL8Q9UI36C-X-C motif chemokine ligand 828
JUNP05412Jun proto-oncogene,27
IL10P22301Interleukin-1025
IL1BP01584Interleukin-1 beta24
MAPK1P10911Mitogen-activated protein kinase 124
CCND1P24864Cyclin D122
HMOX1P09601Heme oxygenase 121
STAT1P42224Signal transducer and activator of transcription 1-alpha/beta21
APPP05067Amyloid beta precursor protein21
VEGF2P35968Vascular endothelial growth factor receptor 220
PTENP60484Phosphatase and tensin homolog20
CRPP02741C-reactive protein20
SELEQ5TI75Selectin E18
F2P16930Coagulation factor II, thrombin17
HIF1AP01892Hypoxia inducible factor 1 subunit alpha17
SOD1P00441Superoxide dismutase 117