Investigating the Molecular Mechanism of Quercetin Protecting against Podocyte Injury to Attenuate Diabetic Nephropathy through Network Pharmacology, MicroarrayData Analysis, and Molecular Docking
Table 1
21 candidate targets with a degree greater than average.
Target
Uniprot ID
Description
Degree
TNF
P01375
Tumor necrosis factor
34
VEGFA
P15692
Vascular endothelial growth factor
33
AKT1
P31749
AKT serine/threonine kinase 1
31
TP53
P04637
Tumor protein p53
29
PTGS2
P35354
Prostaglandin G/H synthase 2
28
CXCL8
Q9UI36
C-X-C motif chemokine ligand 8
28
JUN
P05412
Jun proto-oncogene,
27
IL10
P22301
Interleukin-10
25
IL1B
P01584
Interleukin-1 beta
24
MAPK1
P10911
Mitogen-activated protein kinase 1
24
CCND1
P24864
Cyclin D1
22
HMOX1
P09601
Heme oxygenase 1
21
STAT1
P42224
Signal transducer and activator of transcription 1-alpha/beta