Single-Cell RNA-Sequencing Reveals the Cellular and Genetic Heterogeneity of Skin Scar to Verify the Therapeutic Effects and Mechanism of Action of Dispel-Scar Ointment in Hypertrophic Scar Inhibition

Table 1

Compounds identified in DSO via UPLC-Q-TOF-MS.

Identify	Source^a	Compound Types^b	Molecular Formula	RT (min)	m/z
Tanshinone II b	1	1	C19H20O3	19.82	297.1489
Tanshinone II A	1	1	C19H18O3	22.29	295.1329
Hydroxysafflor yellow A	4	2	C27H32O16	5.25	613.1773
Stachydrine	5	3	C7H13NO2	0.85	144.1019
Senkyunolide	2	4	C12H16O2	15.75	193.1225
Leonurine	5	3	C14H21N3O5	7.1	312.1553
1,2,5,6-tetrahydrotanshinone I	1	1	C18H16O3	18.2	281.1168
Tanshinone II b	1	1	C19H20O3	29.32	297.1486
Amarogentin	3	5	C20H27NO11	5.47	480.1474
Tanshinone I	1	1	C18H12O3	19.92	277.0854
4-Hydroxy-3-butylphenyl peptide	2	6	C12H14O3	9.24	207.1013
Lithospermic acid B	1	7	C36H30O16	9.71	741.1428
Kaempferol	4	8	C15H10O6	8.34	287.055
Apigetrin	4	8	C21H20O10	5.25	433.113
Tanshinone II b	1	1	C19H20O3	19.99	297.148
3,4-Dihydroxycinnamunic acid	1, 2	9	C9H8O4	9.71	181.0495
Kaempferol-3-O-rutinoside	4	5	C27H30O15	6.54	595.166
Prunasin	3	5	C14H17NO6	6.21	318.0942
Miltirone	1	1	C19H22O2	23.02	283.1692
Salvianolic acid C	1	10	C26H20O10	9.71	493.1131
Salvianolic acid G	1	10	C18H12O7	9.24	341.0652
Apigetrin	4	8	C21H20O10	6.54	433.1126
Salvianolic acid G	1	10	C18H12O7	9.71	341.0664
Cryptomeriol	/	11	C20H28O2	20.24	301.2154
Quercetin	3, 4	8	C15H10O7	7.39	303.0496
Safflower yellow A	4	2	C27H30O15	5.25	595.1663
Z-6,8′,7,3′-dipolymer ligustilide	2	6	C24H28O4	22.5	381.2061
Isotanshinone II A	1	1	C19H18O3	22.47	295.1324
Hydroxysafflor yellow A	4	2	C27H32O16	0.81	613.1773
Salvianolic acid A	1	10	C26H22O10	9.71	495.1278
Alkanoic acid	1	7	C27H22O12	9.71	539.1187
6-Hydroxykaempferol	3、4	8	C15H10O7	7.68	303.0493
Rutin	4、5	8	C27H30O16	7.24	611.1615
Quercetin-3-O-α-L-rhamnoside	3, 4	5	C21H20O11	8.34	449.1088
4-Hydroxy-3-butylphenyl peptide	2	6	C12H14O3	9.67	207.1012
Quercetin	3, 4	8	C15H10O7	7.24	303.0497
Rutin	4, 5	8	C27H30O16	7.68	611.161
Prunasin	3	5	C14H17NO6	5.47	296.1126
Kaempferol	4	8	C15H10O6	7.37	287.0542
Neocnidilide	2	6	C12H18O2	17.4	195.1371
Kaempferol	4	8	C15H10O6	8.61	287.055
Methyl tanshinonate	1	10	C20H18O5	18.74	339.1219
Lithospermic acid	1	7	C27H22O12	9.24	561.1004
Hydroxytanshinone II A	1	1	C19H18O4	15.58	311.1276
Quercetin	3, 4	8	C15H10O7	7.93	303.0497
6-Hydroxykaempferol	3, 4	8	C15H10O7	6.77	303.0495
Z-6,8′,7,3′-dipolymer ligustilide	2	6	C24H28O4	22.22	381.2057
Quercetin	3, 4	8	C15H10O7	6.67	303.0497
Miltionone I	1	10	C19H20O4	13.05	313.1441
3,4-Dihydroxycinnamunic acid	1, 2	9	C9H8O4	6.58	181.05
Celery alcohol	4	12	C15H10O5	11.92	271.0598
Hydroxytanshinone II A	1	1	C19H18O4	15.04	311.127
Genkwanin	1, 2	8	C16H12O5	15.27	285.0756
Senkyunolide	2	4	C12H16O2	15.92	193.1222
6-Hydroxykaempferol-3-O-glucoside	3, 4	8	C21H20O12	1.55	465.1031
Protocatechuic aldehyde	1	12	C7H6O3	9.71	139.0398
4-Hydroxy-3-butylphenyl peptide	2	6	C12H14O3	14.38	207.1012
Isoquercetin	3, 4	8	C21H20O12	6.77	465.1028
Hydroxytanshinone II A	1	1	C19H18O4	15.36	311.1274
Safflower yellow A	4	2	C27H30O15	6.85	595.1666
Rutin	4, 5	8	C27H30O16	6.9	611.1612
Safflomin C	4	2	C30H30O14	9.4	615.1712
3,4-Dihydroxycinnamunic acid	1, 2	9	C9H8O4	7.1	181.0492
Danshen neoquinone C	1	14	C16H12O3	19.81	253.0865
Lonicerin	1, 2	8	C15H10O6	7.72	287.0549
Quercetin	3, 4	8	C15H10O7	7.81	303.0497
Apigetrin	4	8	C21H20O10	6.85	433.1127
Hydroxytanshinone II A	1	1	C19H18O4	15.69	311.1275
Senkyunolide	2	4	C12H16O2	12.15	193.1217
Kaempferol-3-O-rutinoside	4	5	C27H30O15	6.36	595.1658
Cryptoacetalide	1	13	C18H22O3	21.32	287.1651
6-Hydroxykaempferol-7-O-glucoside	3、4	5	C21H20O12	7.39	465.1034
Benzoic acid	4	9	C7H6O2	15.75	123.0439
6-Hydroxykaempferol-3-O-glucoside	3, 4	8	C21H20O12	7.68	465.1037

^a1, 2, 3, 4, and 5 indicate S. miltiorrhiza, L. chuanxiong, peach kernel, safflower, and motherwort, respectively; ^b1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14 indicate tanshinones, chalcone glycosides, alkaloids, internal esters, glycosides, phthalides, phenolic acids, flavonoids, organic acids, salvianolic acids, terpenoids, organic compounds, steroids, and quinones, respectively.