Sonchus oleraceus L. Promotes Gastroprotection in Rodents via Antioxidant, Anti-Inflammatory, and Antisecretory Activities

Table 2

Effects of hydroalcoholic extract from S. oleraceus (HES) on oxidative and inflammatory parameters of ulcerated tissue.

	MPO	TNF	GSH	SOD	CAT	GST
Naïve	0.033 ± 0.006	124.4 ± 15.5	915.2 ± 238.4	150.2 ± 13.6	17.57 ± 5.81	359.0 ± 13.1
Vehicle	0.097 ± 0.010^a	589.9 ± 128.6^a	1013 ± 116.2	109.8 ± 45.7^a	6.73 ± 3.91	157.8 ± 17.4
CBX	0.041 ± 0.004^b	293.5 ± 41.65^b	1829 ± 96.1^ab	106.3 ± 7.8	55.03 ± 5.91^ab	325.1 ± 35.4^b
HES	0.050 ± 0.006^b	229.5 ± 20.15^b	2547 ± 127.9^abc	157.6 ± 13.8^abc	41.39 ± 5.76^ab	410.3 ± 46.3^b

Note. Carbonoxolone (CBX, 200 mg/kg); hydroalcoholic extract of S. oleraceus (HES, 300 mg/kg); myeloperoxidase (MPO, mD.O/mg of protein); reduced glutathione (GSH, μg/mg of tissue); superoxide dismutase (SOD, U/mg of protein); catalase (CAT, μmol/min/mg of protein), tumor necrosis factor (TNF), and glutathione S-transferase (GST, μmol/min/mg of protein). Values are expressed as means ± S.E.M (n = 6). One-way ANOVA followed by Bonferroni’s test. ^a vs. naïve group. ^b vs vehicle-treated group. ^c vs carbenoxolone group.