Research Article
Astragali Radix-Coptis Rhizoma Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway
Figure 6
The ARCR herb pair attenuated atherosclerosis via a STAT6-dependent pathway. (a) Body weight, (b) TC, (c) TG, (d) oil red O staining of lipids, immunohistochemical staining of MOMA-2 (macrophage marker) and smooth muscle cells, and Sirius red staining of collagen. (e) Lipid area of oil red O staining. (f-g) Macrophages and smooth muscle cells were assessed using immunohistochemical staining. (h) Collagen of Sirius red staining. (i) Vulnerability index of plaque. (j) ELISA for MMP-9 expression. The data are presented as the means ± SD, n = 10, scale bars: 50 μm. , vs. the control group; , vs. the model group; , vs. ARCR group.
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