Evidence-Based Complementary and Alternative Medicine

Research Article

Antiplasmodial Activity of 80% Methanolic Extract and Solvent Fractions of Stem Bark of Acacia tortilis in Swiss Albino Mice

Table 7

Effects of Acacia tortilis on packed cell volume (PCV), weight, and temperature for the crude extract and dichloromethane fraction of the stem bark of Acacia tortilis in the prophylactic test.


Groups	PCV			Rectal temperature (°C)			Body weight (g)
Groups	D0	D7	% Change	D0	D7	% Change	D0	D7	% Change

10 ml/kg DW	50 .00 ± 1.92	43.50 ± 1.81	−13.00 ± 1.21	36.11 ± 0.12	34.52 ± 0.21	−4.40 ± 0.14	25.34 ± 1.64	22.54 ± 1.32	−11.05 ± 0.83
CHQ 25 mg/kg	48.40 ± 1.03	49.50 ± 1.31^a1	2.27 ± 0.98^a3	36.55 ± 0.17	36.81 ± 0.14	0.71 ± 0.08^a2	23.86 ± 1.42	23.98 ± 0.12	0.50 ± 0.24^a3
100 mg/kg CE	53.80 ± 1.08	48.30 ± 1.02	−10.22 ± 0.75^b2	37.20 ± 0.16	36.13 ± 0.13	−2.88 ± 0.11^b1	24.42 ± 0.54	22.28 ± 0.83	−8.75 ± 0.15^b2
200 mg/kg CE	52.90 ± 0.91	48.20 ± 0.74	−8.88 ± 0.25^b2,a1	36.65 ± 0.24	35.85 ± 0.17	−2.18 ± 0.06	27.21 ± 0.68	25.19 ± 0.65	−7.42 ± 0.18^b1
400 mg/kg CE	53.00 ± 1.66	49.50 ± 1.56^a1	−6.60 ± 1.33^b1,a2	36.45 ± 0.31	35.82 ± 0.26	−1.73 ± 0.16^a1	25.68 ± 1.08	24.33 ± 1.13	−5.25 ± 0.32^a1
10 ml/kg 2% T 80	48.50 ± 1.13	42.40 ± 1.15	−12.58 ± 1.10	36.44 ± 0.34	34.85 ± 0.25	−4.36 ± 0.18	26.83 ± 0.94	23.91 ± 0.76	−10.85 ± 0.41
CHQ 25 mg/kg	48.20 ± 1.00	49.00 ± 1.05^a1	1.66 ± 0.56^a3	36.24 ± 0.14	36.43 ± 0.12	0.52 ± 0.07^a2	23.90 ± 0.87	24.03 ± 1.03	0.55 ± 0.58^a3
100 mg/kg DF	53.20 ± 1.24	48.32 ± 1.14	−9.17 ± 1.02^b3	36.75 ± 0.22	35.83 ± 0.19	−2.50 ± 0.12^b1	24.82 ± 1.48	22.78 ± 1.26	−8.20 ± 0.43^b2
200 mg/kg DF	51.60 ± 1.29	47.73 ± 1.17	−7.50 ± 0.88^a1,b2	36.90 ± 0.27	36.19 ± 0.21	−1.92 ± 0.16	25.55 ± 1.35	23.81 ± 1.07	−6.82 ± 0.96^b1
400 mg/kg DF	48.80 ± 1.61	46.26 ± 1.57	−5.20 ± 1.08^a2,b1	36.60 ± 0.31	36.01 ± 0.29	−1.61 ± 0.20^a1	26.25 ± 1.32	24.93 ± 1.28	−5.04 ± 0.92^a2

Data are expressed as mean ± SEM; n = 6, a = compared to the negative control, b = compared to the positive control, c = compared to 100 mg/kg dose, d = compared to 200 mg/kg dose, e = compared to 400 mg/kg dose, ¹, ², ³, = negative and positive controls for the dichloromethane fraction, D0 = day 0, D4 = day 4, DW = distilled water, CE = crude extract, DF = dichloromethane fraction, T 80 = tween 80, and CHQ = chloroquine.