Elucidation of Potential Targets of San-Miao-San in the Treatment of Osteoarthritis Based on Network Pharmacology and Molecular Docking Analysis

Figure 2

Topological analysis of intersection targets between OA-related targets and targets of SMS active compounds. The 108 intersection targets shown in protein-protein interaction network are performed for topology network analysis twice. The parameters such as BC, CC, DC, EC, IC, and LAC represent the filter conditions. The yellow rectangles represent the key targets in the subnetwork obtained from topology analysis. The active compounds-key targets network of each screening analysis is presented with the degree centrality of key targets and the intersection targets among CZ, HB, and NX.