Pinocembrin Reduces Keratinocyte Activation and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in BALB/c Mice through the Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Pathway

Figure 1

Anti-inflammatory and antiproliferative effects of pinocembrin on human keratinocytes. (a) HaCaT cells were pretreated with or without pinocembrin for 6 h and then cultured in the presence or absence of IFN-γ for 18 h; mRNA expression was quantified using qPCR. (b) Inflammatory cytokines and cell viability were determined using an ELISA and MTT assay, respectively. (c) HaCaT cells were pretreated with or without pinocembrin for 6 h and then cultured in the presence or absence of IFN-γ for 48 h; mRNA expression was quantified using qPCR. Data are expressed as mean ± SD. , , and compared with the IFN-γ-alone group, determined using Student’s two-tailed t-test.

(a)

(b)

(c)