Pinocembrin Reduces Keratinocyte Activation and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in BALB/c Mice through the Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Pathway

Figure 5

Histopathological analysis of mouse dorsal skin. (a) H&E stain (magnification 100×) ∗: inflammation. Arrow: hyperplasia. Arrowhead: hyperkeratosis. (b) Epidermal thickness. (c) Semiquantitative recording of histopathological lesions. On day 6 after IMQ challenge, mouse dorsal skin samples were harvested and then subjected to H&E staining. Inflammation, hyperplasia, and hyperkeratosis were semiquantified as described in Materials and Methods. Data are expressed as mean ± SEM (n = 5 for IMQ-treated animals and n = 3 for Naive). and compared with the vehicle group, determined using Student’s two-tailed t-test (for epidermal thickness) or the Mann–Whitney U test (for the histopathological score).

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