Exploring the Protective Effect and Mechanism of Buddlejae Flos on Sodium Selenite-Induced Cataract in Rats by Network Pharmacology, Molecular Docking, and Experimental Validation

Table 3

Detailed information on common targets.

No.	Uniprot ID	Target gene	Target protein	Major molecular function
1	P05231	IL6	Interleukin-6	Cytokine
2	P12004	PCNA	Proliferating cell nuclear antigen	DNA-binding
3	P09211	GSTP1	Glutathione S-transferase P	Transferase
4	P15692	VEGFA	Vascular endothelial growth factor A	Growth factor
5	P06400	RB1	Retinoblastoma-associated protein	Repressor
6	P42574	CASP3	Caspase-3	Protease
7	Q16665	HIF1A	Hypoxia-inducible factor 1-alpha	Activator
8	Q9Y6K9	IKBKG	NF-kappa-B essential modulator	DNA damage
9	P01308	INS	Insulin	Hormone
10	P25054	APC	Adenomatous polyposis coli protein	Wnt signaling pathway
11	P11511	CYP19A1	Aromatase	Oxidoreductase
12	P03372	ESR1	Estrogen receptor	Receptor
13	P35354	PTGS2	Prostaglandin G/H synthase 2 ·	Oxidoreductase
14	P08183	ABCB1	ATP-dependent translocase ABCB1	Translocase
15	P22748	CA4	Carbonic anhydrase 4	Lyase
16	P14780	MMP9	Matrix metalloproteinase-9	Hydrolase
17	P14679	TYR	Tyrosinase	Oxidoreductase
18	P35869	AHR	Aryl hydrocarbon receptor	Receptor
19	O14746	TERT	Telomerase reverse transcriptase	Nucleotidyltransferase
20	P00533	EGFR	Epidermal growth factor receptor	Host cell receptor for virus entry
21	P30530	AXL	Tyrosine-protein kinase receptor UFO	Receptor
22	P27986	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha	Host-virus interaction
23	P51955	NEK2	Rine/threonine-protein kinase Nek2	Transferase
24	P31749	AKT1	RAC-alpha serine/threonine-protein kinase	Transferase
25	P35228	NOS2	Nitric oxide synthase, inducible	Calmodulin-binding
26	P01375	TNF	Tumor necrosis factor	Cytokine
27	P60568	IL2	Interleukin-2	Growth factor
28	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Transferase
29	P04637	TP53	Cellular tumor antigen p53	Repressor
30	P05121	SERPINE1	Plasminogen activator inhibitor 1	Protease inhibitor
31	P31639	SLC5A2	Sodium/glucose cotransporter 2	Ion transport
32	P26358	DNMT1	DNA (cytosine-5)-methyltransferase 1	Chromatin regulator
33	P37231	PPARG	Peroxisome proliferator-activated receptor gamma	Receptor
34	P10415	BCL2	Apoptosis regulator Bcl-2	Apoptosis
35	P08253	MMP2	72 kD a type IV collagenase	Hydrolase
36	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Oxidoreductase
37	P20839	IMPDH1	Inosine-5′-monophosphate dehydrogenase 1	Oxidoreductase
38	P03956	MMP1	Interstitial collagenase	Hydrolase