Exploring the Protective Effect and Mechanism of Buddlejae Flos on Sodium Selenite-Induced Cataract in Rats by Network Pharmacology, Molecular Docking, and Experimental Validation

Table 4

Docking results of core bioactive compounds and core common targets.

Targets	Compounds	Binding Energy (kcal/mol)	Combination type
Luteolin	AKT1	−8.58	Hb, Hi, π-stacking
Luteolin	TP53	−7.99	Hb, Hi
Luteolin	CASP3	−8.21	Hb, Hi, π-stacking
Luteolin	EGFR	−7.98	Hb, Hi, π-stacking
Luteolin	TNF	−8.44	Hb, Hi, π-stacking
Apigenin	AKT1	−7.86	Hb, Hi, π-stacking
Apigenin	TP53	−7.7	Hb, Hi
Apigenin	CASP3	−7.98	Hb, Hi, π-stacking
Apigenin	EGFR	−8.01	Hb, Hi, π-stacking
Apigenin	TNF	−7.4	Hb, Hi, π-stacking
Acacetin	AKT1	−7.35	Hb, Hi, π-stacking
Acacetin	TP53	−7.49	Hb, Hi
Acacetin	CASP3	−7.16	Hb, Hi, π-stacking
Acacetin	EGFR	−7.98	Hb, Hi, π-stacking
Acacetin	TNF	−8.07	Hb, Hi, π-stacking

“Hb” represents hydrogen bonds and “Hi” represents hydrophobic interactive.