Research Article
Piperine Enhances the Antimalarial Activity of Curcumin in Plasmodium berghei ANKA-Infected Mice: A Novel Approach for Malaria Prophylaxis
Table 1
Semiquantitative analysis of liver histopathology.
| | Group | Histopathological parameters | Overall lesion scores | | Hyperplasia Kupffer cells | Sinusoid congestion | Portal inflammation | Necrosis |
| | Control | 3.50 ± 0.50 | 3.50 ± 0.50 | 3.50 ± 0.50 | 4.00 ± 0.00 | 14.5/20 | | ART | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 4/20 | | CUR | 2.50 ± 0.50 | 1.00 ± 0.00 | 1.50 ± 0.50 | 2.50 ± 0.50 | 7.5/20 | | CUR + PIP | 1.50 ± 0.50 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 4.5/20 | | PIP | 3.50 ± 0.50 | 2.00 ± 0.00 | 2.00 ± 0.00 | 3.00 ± 0.00 | 10.5/20 |
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The data are presented as mean ± SEM.
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