The Potential Hepatoprotective Effect of Paeoniae Radix Alba in Thioacetamide-Induced Acute Liver Injury in Rats

Figure 3

Paeoniae radix alba suppressed the release of NF-κBp65 and proinflammatory proteins. The higher dose of Paeoniae Radix Alba (200 mg/kg) significantly reduced the protein expression of NF-κBp65, iNOS, COX-2, TNF-α, and IL-6. Data are expressed as the mean ± standard error of the mean (n = 7). , , and versus the normal group and ^∗, ^∗∗ versus the thioacetamide control group. Normal: received distilled water only; control: thioacetamide-induced acute liver injury treated with distilled water; silymarin: thioacetamide-induced acute liver injury treated with silymarin (100 mg/kg); PR100: thioacetamide-induced acute liver injury treated with Paeoniae Radix Alba (100 mg/kg); and PR200: thioacetamide-induced acute liver injury treated with Paeoniae Radix Alba (200 mg/kg).