Cannabis Extract Effects on Metabolic Parameters and Gut Microbiota Composition in a Mice Model of NAFLD and Obesity

Figure 4

Effect on gluconeogenesis, energy homeostasis, lipid metabolism, and endocannabinoid receptors in the liver. Male C57BL/6 J mice fed high-fat diet supplemented with CN1 or CN2 or CN6 extracts 5 mg/kg BW for 8 weeks. (a) G6pase mRNA levels. (b) PEPCK mRNA levels. (c) CD36 mRNA levels. (d) PGC-1α mRNA levels. (e) PPARα mRNA levels. (f) p-AMPK/AMPK protein levels. (g) CB2 receptor protein expression. (h) CB1 receptor protein expression. All values are expressed as mean ± SEM (n = 6–8). Columns marked with are different from ND (). Columns marked with different letters are significantly different ().

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