Medicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Mentha spicata

Table 10

Toxicity study of Mentha spicata.

Parts used	Extracts	Experimental approaches	Key results	References
Aerial parts	Methanol extract	The animals treated with a single dose of 5000 mg/kg of M. spicata extract by oral gavage	No mortality during the observation period	[113]
			No toxicologically significant hematological and biochemical changes
			Any morphological changes in the heart, liver, kidney, and lung tissues of the rats
			LD50 is considered to be >5000 mg/kg
Leaves	Ethanolic extract	The animals treated with a single dose of 10000, 12000, 14000, 16000, and 18000 mg/kg BW of M. spicata extract by oral gavage	NOEL dose for M. spicata was 10000 mg/kg	[114]
			100% mortality at 18000 mg/kg BW
			LD50 = 13606 mg/kg BW
Leaves	Ethanolic extract	The animals treated with 500, 1000, and 1500 mg/kg BW daily for 28 days	No signs of toxicity; no mortalities; no significant change in bodyweight; significant increase in WBC, Lym, and MCHC levels; significant reduction in HCT level; significant increase in AST levels; unaffected serum creatinine and urea; no significant histopathological change	[114]
Whole plant	Methanol extract	Mice treated with a single dose of 500, 1000, and 2000 mg/kg of M. spicata extract by oral gavage	No mortality during the observation period	[97]
Aerial parts	Essential oil	EO (0.05–0.5 mL) orally administered to mice (Mus musculus L., average weight 30.0 g, age 3 months)	LD50 = 8342.33 μL/kg	[66]
Leaves	Ethanolic extract	The animals treated with 500, 1000, and 1500 mg/kg BW daily for 28 days	No signs of toxicity; no mortalities; no significant change in bodyweight; significant increase in WBC, Lym, and MCHC levels; significant reduction in HCT level; significant increase in AST levels; unaffected serum creatinine and urea; no significant histopathological change	[114]
Whole plant	Methanol extract	Mice treated with a single dose of 500, 1000, and 2000 mg/kg of M. spicata extract by oral gavage	No mortality during the observation period	[97]
Aerial parts	Essential oil	EO (0.05–0.5 mL) orally administered to mice (Mus musculus L., average weight 30.0 g, age 3 months)	LD50 = 8342.33 μL/kg	[66]