Review Article

Medicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Mentha spicata

Table 2

Chemical compounds of M. spicata.

CountryPart usedCompoundsReference

MoroccoAerial partsCarvone (33.14%)[25]
trans-Carveol (20.06%)
β-Caryophyllene (4.41%)
1,8-Cineole (3.99%)
Germacrene D (3.14%)
Menthone (2.19%)
α-Pinene (1.06%)
Aerial partsCarvone (47.30–69.19%)[26]
Limonene (4.48–15.43%)
trans-4-Caranone (0.82–4.63%)
iso-Dihydrocarveol acetate (0.06–2.66%)
ρ-Mentha-3,8-diene (0.85–1.32%)
Aerial partsCarvone (57.11%)[27]
Limonene (27.77%)
3-Carene (1.01%)
Germacrene D (0.65%)
Aerial partsCarvone (29.00%)[28]
trans-Carveol (14.00%)
1,8-Cineole (7.30%)
Dihydrocarveol (l4.50%)
Carvyl acetate-Z (6.70%)
Germacrene D (3.90%)

ItalyAerial partsCarvone (39.13 to 59.26%)[29]
1,8-Cineole (1.07–9.02%)
Dihydrocarveol (2.36–5.94%)
Germacrene D (1.79–4.11%)
Limonene (5.9–11.40%)
trans-Carvyl acetate (0.72–5.90%)
Aerial partsp-Cymene (33.9%)[30]
iso-Piperitone (23.7%)
Piperitone (6.9%)
Menthone (21.8)
p-Cymen-8-ol (19.6)
β-Linalool (15.2%)

Czech RepublicAerial partsCarvone (0.7–59.1%)[3]
Menthol (1.1%–14.9%)
p-Menthone (1.1%–4.4%)
Piperitone oxide (34.1%)
Germacrene D (14.6%)
β-Caryophyllene (2.2–3%)
Dihydrocarvone (11.8–12.7%)
cis-Jasmone (1.6–1.8%)

TurkeyAerial partsPiperitenone oxide (25.84%)[31]
Pulegone (24.72%)
cis-Piperitenone oxide (12.55%)
Limonene (1.59%)
Aerial partsCarvone (34.70 to 79.70%)[24]
1,8-Cineole (3.40–33.80%)
β-Pinene (0.87–5.29%)
Limonene (1.10–22.10%)
Menthone (0.20–2.73%)
Pulegone (1.70–9.94%)
Aerial partsCarvone (48.6–57.9%)[32]
ρ-Cymene (9.6–20.5%)
1,8-Cineole (14.6–19.3%)
Carvacrol (0.1–3.5%)
α-Pinene(2.3–4.3%)
Phenolic acidsRosmarinic acid derivatives (88%)[30]
Salvianolic acids (5.6%)
Caffeoylquinic acids (1.2%)
Hydroxycinnamic (1.1%)
Fatty acidsPalmitic acid (5.11 0.41%)[33]
Stearic acid (1.92 ± 0.21%)
Oleic acid (8.19%)
Linoleic acid (31.14%)
α-Linolenic acid (48.17%)
γ-Linolenic acid(2.07%)
Stearidonic acid (3.02%)

IndiaAerial partsCarvone (49.62–76.65%)[34]
Limonene (9.57–22.31%)
1,8-Cineole (1.32–2.62%)
trans-Carveol (0.3–1.52%)
PhenolicsPentadecanoic acid (7.47%)[35]
7-Oxabicyclo[4.1.0] heptane (9.56%)
3-Penten-2-one,4-(2,2,6-trimethyl-7-oxabicyclo[4.1.0] hept-1-yl)-,(E)-(12.20%) stigmast-4-EN-3-one (18.99%)
Aerial partstrans-Muurola-4 (14%)[36]
5-Diene (27.28%)
Piperitenone oxide (22.22%)
β-Caryophyllene (10.48%)
Geranyl propanoate (6.55%)
Sibirene (3.45%)
Borneol (1.98%)
Allo-ocimene (1.71%)
β-Elemene (1.34%)
Germacrene D-4-ol (1.02%)
Aerial partsCarvone (57.49–72.47%)[37]
Limonene (10.70–24.81%)
Myrcene (0.25–4.36%)
1,8-Cineole (0.2–2.02%)
Aerial partsCarvone (48.60%)[38]
Limonene (11.30%)
cis-Carveol (21.30%)
Linalool (1.30%)
1,8-Cineole (2.55%)
cis-Carvyl acetate (2.10%)
cis-Dihydrocarvone (1.30%)
IranAerial partsCarvone (65.15–74.21%)[39]
Limonene (12.22–20.55%)
cis-Dihydrocarvone (2.34–11.13%)
Caryophyllene (1.13–5.06%)
Aerial partsCarvone (42.74–54.34%)[4]
trans-Dihydrocarvone (21.58%)
1,8-Cineole (8.41–21.78%)
Pulegone (6.83%)
Limonene (5.2–6.1%)
β-Caryophyllene (3.05%)
Linalool (5.82%)
trans-Dihydrocarvone (3.18%)
Aerial partsCarvone (49.91%–56.92%)[40]
Piperitone oxide (10.69%–11.72%)
1,8-Cineole (3.78–3.34%)
Limonene (7.33–6.61%)
Germacrene D (6.26–1.90%)
Aerial partsCarvone (54.34%)[41]
1,8-Cineole (8.41–22.71%)
Piperitenone oxide (58.87%)
3,8-Menthadiene (21.58%)
α-Pinene (0.95–1.68%)
2-Cyclohexen (42.74%)
Borneol (5.82%)
DL-Limonene (5.2%)
Pulegone (6.83%)

MalaysiaFlavonoids leavesCatechin (14–14.4%)[42]
Epicatechin (15.6–16.3%)
Rutin 1 (4.8–16.1%)
Myricetin (4.1–11.7%)
Luteolin (9.3–65.7%)
Apigenin (27–39.2%)
Naringenin (5.4–24.9%)

AlgeriaLeavesCarvone (59.40%)[7]
Limonene (6.12%)
1,8-Cineole, germacrene D (04.66%)
β-Caryophyllene (2.969%)
β-Bourbonene (2.796%)
α-Terpineol (1.986%)
Terpinene-4-ol (1.120%)

BrazilAerial partsCarvone (39.42–72.28%)[43]
Pulegone (5.53–10.48%)
Carveol (3.30–4.98%)
Cineol (1.49%)
LeavesLinalool (58.51%)[6]
Carvone (15.1%)
α-Terpineol (1.43%)
β-Caryophyllene (2.02%)
Eucalyptol (1.04%)
Terpinen-4-ol (5.73%)
LeavesPiperitone (81.18%)[44]
Piperitenone (14.75%)
α-Pinene (0.51%)
Limonene (1.47%)
Aerial partsLimonene (2.04–19.91%),[45]
Isomenthone (0.46–11.60%)
Menthone (0.46–11.60%)
1,8-Cineole (eucalyptol) (2.98–8.10%)
d-Carvone (31.35–60.07%)
β-Pinene (2.41–4.27%)
Isomenthone (4.46%)
Pulegone (6.68–53.65%)

ChinaAerial partsCarvone (46.7–65.4%)[46]
Limonene (0.3–1.8%)
Linalool (0.6 6.9%)
Menthone (1.5–4.7%)
Dihydrocarvone (0.8–15.7%)
Dihydrocarveol acetate (0.2–7%)

ChinaAerial partsCarvone (65.33%)[11]
Limonene (18.19%)
Dihydrocarvone (2.97%)
Camphene (2.34%)

HungaryLeavesCarvone (35.9–60.5%)[47]
Citronellol (10.1–13.4%)
Limonene (1.6–9.4%)
Menthone (3.2–4.4%)
α-Terpineol (2.1–3%)
cis-Dihydrocarvone (1.5–2.2%)
(e)-b-Caryophyllene (1.5–2.1%)

JordanAerial partsCarvone (49.5%)[48]
Limonene (16.1%)
1,8-Cineole (8.7%)
cis-Dihydrocarvone (3.9%)
β-Caryophyllene (2.7%)
Germacrene D (2.1%)
β-Pinene (1.1%)

Abu DhabiLeavesCarvone (14.79–87.11%)[49]
Dihydrocarvone (0.09–0.19%)
Cineole (0.2–0.6%)
Limonene (1.94–9.72%)
Menthol (0.06–0.19%)
Linalool (0.09–0.23%)
α-Pinene (0.05–0.3%)

RomaniaPhenolics, 70% ethanolFerulic acid (27.32%)[50]
Sinapic acid (6.60%)
p-Coumaric acid (15.24%)
Luteolin (4.68%)

TunisiaAerial partsCarvone (39.21–75.53%)[51]
1,8-Cineole (7.24–12.49%)
Limonene (6.07–18.45%)
cis-Dihydrocarveol (1.17–6.56%)
trans-Carveol (0–5.22%)
Pulegone (38.74%)
Menthone (28.56%)
Menthol (5.64%)

BangladeshAerial partsCarvone (73.29%)[52]
D-Limonene (7.59%)
Dihydrocarvone (3.83%)
α-Bourbonene (1.67%)
trans-Sabinene hydrate (1.57%)
trans-Carveol (1.25%)
Dihydrocarveol (1.12%)
Eucalyptol (1.01%)

SerbiaAerial partsCarvone (49.5%)[53]
Menthone (21.9%)
Piperitone 0.6%)
β-Bourbonene (26.8%)
β-Caryophyllene (0.7%)
Germacrene A(0.5%)

PalestineAerial partsLimonene (6.23–9.79%)[54]
Carvone (36.9–76.82%)
Sabinene (0.14–5.51%)
cis-Dihydrocarvone (0.65–4.59%)
β-Caryophyllene (0.81–3.87%)
Dihydrocarveol (2.27–13.76%)

CyprusAerial partsCarvone (ketone: 69.23–74.27%)[55]
Limonene (alkene: 10.42–11.39%)
1,8-Cineole (alcohol: 5.28–5.99%)
β-Pinene (alkene: 1.13–1.25%)
β-Caryophyllene (alkene: 0.80–1.29%)
Germacrene D (alkene: 2.09–3.13%)
Bicyclogermacrene (0.60–1.01%)

PakistanAerial partsCarvone (51.7%)[5]
cis-Carveol (24.3%)
Limonene (5.3%)
1,8-Cineol (4.0%)
cis-Dihydrocarvone (2.2%)
Carvyl acetate (2.1%)
cis-Sabinene hydrate (1.0%)