Review Article

Medicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Mentha spicata

Table 3

Antifungal activity of Mentha spicata.

Used partExtractsUsed methodTested strainsKey resultsReferences

RootHexane extractDisc diffusion methodA. nigerMIC > 356 μg/mL[62]
C. albicansMIC > 356 μg/mL
C. neoformansMIC > 356 μg/mL
M. audouiniiMIC = 32 μg/mL
RootChloroform extractA. nigerMIC > 356 μg/mL[62]
C. albicansMIC > 356 μg/mL
C. neoformansMIC = 64 μg/mL
M. audouiniiMIC = 64 μg/mL
RootEthyl acetate extractA. nigerMIC = 128 μg/mL[62]
C. albicansMIC = 128 μg/mL
C. neoformansMIC = 128 μg/mL
M. audouiniiMIC = 32 μg/mL
RootMethanol extractA. nigerMIC = 64 μg/mL[62]
C. albicansMIC = 128 μg/mL
C. neoformansMIC = 128 μg/mL
M. audouiniiMIC > 356 μg/mL

RootEthanol extractDisc diffusion methodA. nigerMIC = 64 μg/mL[62]
C. albicansMIC = 128 μg/mL
C. neoformansMIC = 128 μg/mL
M. audouiniiMIC > 356 μg/mL
RootToluene extractA. nigerMIC > 356 μg/mL[62]
C. albicansMIC = 64 μg/mL
C. neoformansMIC > 356 μg/mL
M. audouiniiMIC = 128 μg/mL
RootN-butanol extractA. nigerMIC = 128 μg/mL[62]
C. albicansMIC = 64 μg/mL
C. neoformansMIC > 356 μg/mL
M. audouiniiMIC = 128 μg/mL
RootN-propanol extractA. nigerMIC = 64 μg/mL[62]
C. albicansMIC = 64 μg/mL
C. neoformansMIC = 32 μg/mL
M. audouiniiMIC = 128 μg/mL

RootIsopropanol extractDisc diffusion methodA. nigerMIC = 128 μg/mL[62]
C. albicansMIC = 128 μg/mL
C. neoformansMIC > 356 μg/mL
M. audouiniiMIC > 356 μg/mL
RootWater extractA. nigerMIC = 32 μg/mL[62]
C. albicansMIC = 64 μg/mL
C. neoformansMIC = 32 μg/mL
M. audouiniiMIC = 16 μg/mL

Aerial partsEssential oilMicrodilution methodCandida glabrataMIC = 256 μg/mL[48]
Aerial partsVolatile oilAgar well diffusion methodR. solaniInhibition = 100% at dose of 12 μL[64]
A. solaniInhibition = 100% at dose of 12 μL
F. oxysporum f.sp. radicis-lycopersiciInhibition = 100% at dose of 12 μL
V. dahliaeInhibition = 100% at dose of 12 μL

LeavesEssential oilSpots methodA. niger 2CA 936Ф = 36.0 ± 1.0 mm[65]
A. flavus NRRL 391Ф = 43.7 ± 0.6 mm
C. albicans (ATCC 1024)Ф = 44.3 ± 1.1 mm

LeavesEssential oilDisc methodA. niger 2CA 936Ф = 32.0 ± 1.0 mm[65]
A. flavus NRRL 391Ф = 36.0 ± 2.0 mm
C. albicans (ATCC 1024)Ф = 23.3 ± 0.6 mm

Aerial partsEssential oilsDisc diffusion method
Microdilution broth susceptibility assay
Aspergillus nigerФ = 26.9 ± 1.2 mm[5]
MIC = 0.07 ± 0.00 μg/mL
Mucor mucedoФ = 26.2 ± 0.8 mm
MIC = 0.08 ± 0.00 μg/mL
Fusarium solaniФ = 25.2 ± 1.0 mm
MIC = 0.09 ± 0.00 μg/mL
Botryodiplodia theobromaeФ = 23.0 ± 1.1 mm
MIC = 0.11 ± 0.01 μg/mL
Rhizopus solaniФ = 26.3 ± 0.8 mm
MIC = 0.09 ± 0.00 μg/mL

Aerial partsEssential oilAbsidia ramosaMycelial inhibition = 100%[66]
Alternaria alternataMycelial inhibition = 100%
Aspergillus fumigatusMycelial inhibition = 100%
Aspergillus glaucusMycelial inhibition = 100%
Aspergillus luchuensisMycelial inhibition = 91.72 ± 0.36%
Aspergillus nigerMycelial inhibition = 100%
Aspergillus terreusMycelial inhibition = 75.67 ± 0.74%
Aspergillus unguisMycelial inhibition = 100%
Cladosporium cladosporioidesMycelial inhibition = 100%
Curvularia lunataMycelial inhibition = 100%
Fusarium oxysporumMycelial inhibition = 100%
Mucor spp.Mycelial inhibition = 100%
Mycelia steriliaMycelial inhibition = 100%
Penicillium citrinumMycelial inhibition = 100%
Penicillium italicumMycelial inhibition = 100%
Penicillium luteumMycelial inhibition = 100%
Penicillium purpurogenumMycelial inhibition = 100%
Rhizopus stoloniferMycelial inhibition = 100%
Spondylocladium australeMycelial inhibition = 100%

Essential oilsDisc diffusion methodA. nigerMIC = 6.25 μg/mL
MBC = 12.50 μg/mL
[11]
LeavesHexaneAgar well diffusion techniquesSaccharomyces cerevisiaeФ = 25[63]
Aspergillus nigerФ = 26 mm
LeavesPetroleum etherAgar well diffusion techniquesSaccharomyces cerevisiaeФ = 24 mm[63]
Aspergillus nigerФ = 27 mm
Aerial partsEssential oilsDisc diffusion methodCandida albicansMIC < 3.19 μg/mL[67]
Candida tropicalisMIC < 3.19 μg/mL
LeavesEthanol extractFusarium oxysporum f.sp. lentisInhibition = 1oo%[68]
LeavesEssential oilAgar diffusion methodAspergillus niger (ATCC 9763)Ф = 19 mm[69]
Candida albicans (ATCC 7596)Ф = 18 mm

Essential oilAgar well diffusion methodAspergillus nigerФ = 15.7 ± 0.09 mm[70]
Aspergillus spp.,Ф = 13 ± 0.13 mm
Candida albicansФ = 11.8 ± 0.10 mm
Rhizopus nigricansNo inhibition

LeavesEssential oilAgar diffusion methodCandida albicansФ = 16 mm at concentration of 100 mg/mL[71]
LeavesEssential oilAgar well diffusion methodMucor ramamnianus (ATCC 9314)Ф = 40 mm[72]
Aspergillus ochraceus (NRRL 3174)Ф = 43 mm
Candida albicans (IPA 200)Ф = 21 mm
Saccharomyces cerevisiae (ATCC 4226 A)Ф = 25 mm