Medicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Mentha spicata

Table 7

Anti-inflammatory activity of Mentha spicata.

Used part	Extracts	Experimental approach	Key results	References
Whole plant	Methanol extract	Carrageen-induced paw edema method	Significant dose-dependent reduction of paw edema	[97]
Leaves	Hexane extract	Carrageenan-induced paw edema in rats	Reduced the inflammation with less effectiveness	[98]
			Reduced the inflammation by 0–20%
	Ethyl acetate extract		Reduced the inflammation by 9–85%
	Chloroform fraction		The inflammation did not decrease
	Aqueous fraction		Enhances inflammation by about 7–11%
	Hexane extract	Cotton pellet-induced granuloma in rats	Reduced inflammation with 20%
	Ethyl acetate extract		Reduced inflammation with 65%
	Chloroform fraction		Reduced inflammation with 20%
	Aqueous fraction		Reduced inflammation with 54%
Leaves	Methanol extract	Irinotecan-induced mucositis in mice	Significantly decreased both jejunal tissue IL-1β and fecal β-glucuronidase activity	[99]
			Improvements in mucositis features