Review Article
Medicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Mentha spicata
Table 7
Anti-inflammatory activity of Mentha spicata.
| Used part | Extracts | Experimental approach | Key results | References |
| Whole plant | Methanol extract | Carrageen-induced paw edema method | Significant dose-dependent reduction of paw edema | [97] | Leaves | Hexane extract | Carrageenan-induced paw edema in rats | Reduced the inflammation with less effectiveness | [98] | Reduced the inflammation by 0–20% | Ethyl acetate extract | Reduced the inflammation by 9–85% | Chloroform fraction | The inflammation did not decrease | Aqueous fraction | Enhances inflammation by about 7–11% | Hexane extract | Cotton pellet-induced granuloma in rats | Reduced inflammation with 20% | Ethyl acetate extract | Reduced inflammation with 65% | Chloroform fraction | Reduced inflammation with 20% | Aqueous fraction | Reduced inflammation with 54% |
| Leaves | Methanol extract | Irinotecan-induced mucositis in mice | Significantly decreased both jejunal tissue IL-1β and fecal β-glucuronidase activity | [99] | Improvements in mucositis features |
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