Medicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Mentha spicata

Table 8

Antidiabetic effects of Mentha spicata.

Part used	Extracts	Dose	Model	Keys results	References
Leaves	Aqueous ethanolic extract	200 mg/kg and 400 mg/kg bodyweight	Alloxan-induced hyperglycemic rats	Reduced blood glucose level, reduced serum cholesterol, triglycerides, LDL, and VLDL and increased bodyweights and HDL levels	[101]
Leaves	Phenolic extract	200 mg/kg bodyweight	Alloxan-induced hyperglycemic rats	Significant decrease in glucose concentration of blood serum; significant decrease in cholesterol and TG; significant increase in plasma HDL; significant decrease in plasma LDL, VLDL	[100]
Leaves	Aqueous extract	300 mg/kg bodyweight	Alloxan-induced hyperglycemic rats	Decreased blood glucose level; decreased bodyweight; significant reduction of total cholesterol, triglyceride, and LDL-cholesterol levels; significant increase in plasma HDL; significant reduction in the level of MDA	[13]
Roots	Butanol extract	100 mg/kg bodyweight	Streptozotocin-induced hyperglycemic rats	Increased bodyweight; reduced blood glucose	[8]
Leaves	Essential oil	200 μL	α-Glucosidase inhibitory assay	IC50 = 86.93 ± 2.43 μg/mL	[86]
		250 μL	α-Amylase inhibitory assay	IC50 = 101.72 ± 1.86 μg/mL