Study on the Mechanism of Bu-Shen-He-Mai Granules in Improving Renal Damage of Ageing Spontaneously Hypertensive Rats by Regulating Th17 Cell/Tregs Balance

Table 1

Main botanical compositions of BSHM granules.

Herb	English name	Medicinal parts	Amount in application (g)
La radice di Astragalus membranaceus (HuangQi)	Astragalus membranaceus	Rhizome	30
Branchi e foglie di piante parassitarie della famiglia moraceae (SangJisheng)	Taxilli	Leaf	15
Polygonatum plants (huangjing)	Polygonatum sibiricum	Rhizome	15
Fruit of Ligustrum lucidum (NcZhenzi)	Ligustrum lucidum	Fruit	15
Dry roots of Achyranthes bidentata (NiuXi)	Achyranthis bidentatae radix	Rhizome	15

SR0987 (Selleck, Shanghai, China) is an RORγt agonist with an EC50 of 800 nM. SR0987 increases IL-17 expression while reducing PD-1 expression. SR0987 was administered via a single intraperitoneal injection (7.14 mg/kg).