Study on the Mechanism of Bu-Shen-He-Mai Granules in Improving Renal Damage of Ageing Spontaneously Hypertensive Rats by Regulating Th17 Cell/Tregs Balance

Table 2

Top 10 up/downregulated mRNAs in transcriptome sequencing (n = 3, BSHM vs. SHR).

Gene name	Regulation	values	log2FoldChange	Description
LOC100912599	Up	0.0002	5.5696	NADH dehydrogenase
Mapk8ip2	Up	0.0352	4.4850	Mitogen-activated protein kinase 8 interacting protein 2
Tex101	Up	0.0400	4.0397	Testis expressed 101
LOC103690026	Up	0.0003	3.8898	S-Adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase-like
Nsun4	Up	0.01967	3.8131	NOP2/Sun RNA methyltransferase family member 4
LOC103694874	Up	3.8154	3.7990	Stromelysin-3
Tat	Up	0.0266	3.6292	Tyrosine aminotransferase
Pimreg	Up	0.0428	3.4619	PICALM interacting mitotic regulator
Efna3	Up	0.0490	3.3519	Ephrin A3
LOC100911225	Up	0.0456	3.2497	Fucose mutarotase-like
Derl3	Down	0.0100	−5.5691	Derlin 3
Hprt1	Down	0.0018	−5.1367	Hypoxanthine phosphoribosyltransferase 1
LOC100910021	Down	0.0194	−5.0797	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like
Btnl9	Down	0.0098	−4.7328	Butyrophilin-like 9
Hemgn	Down	0.0356	−4.1434	Hemogen
LOC103692165	Down	0.0089	−3.7819	Rhotekin
Nhlrc4	Down	0.0260	−3.7758	NHL repeat containing 4
Cracr2b	Down	3.4593	−3.7475	Calcium release activated channel regulator 2B
Gstm3	Down	0.0219	−3.6136	Glutathione S-transferase mu 3
Vwa5a	Down	0.0137	−3.5798	von Willebrand factor A domain containing 5A