Salvianolic Acid B Attenuates Iopromide-Induced Renal Tubular Epithelial Cell Injury by Inhibiting the TLR4/NF-κB/NLRP3 Signaling Pathway

Figure 1

Effect of iopromide and Sal B in HK-2 cell viability. (a) Several doses of iopromide were found to cause a significant decrease in cell viability n = 5. Data are the mean ± SD. , vs. control group. (b) Different doses of Sal B were found to reduce HK-2 cells against iopromide-induced injury. n = 5. Data are the mean ± SD. vs. control group; ^#, ^## vs. 150 mgI/mL iopromide group. Several concentrations of Sal B counteracted iopromide-induced apoptosis, Bax/Bcl-2, and cleaved caspase-3 protein levels in HK-2 cells. (c, d) Sal B counteracted the iopromide-induced apoptosis. n = 6. Data are the mean ± SD. vs. control group; ^## vs. iopromide group. (e) The protein levels of Bax/Bcl-2 and cleaved caspase-3 were significantly increased in iopromide-treated cells. These changes were lowered in the 100 μmol/L Sal B group n = 3. Data are the mean ± SD. , vs. control group; ^#, ^## vs. iopromide group.

(a)

(b)

(c)

(d)

(e)