Validation of Antidiabetic and Antihyperlipidemic Effects of 80% Methanolic Extract of the Lonchocarpus laxiflorus Leaves in Streptozotocin-Induced Diabetic Swiss Albino Mice

Table 2

The hypoglycemic effect of the crude extract in normoglycemic mice.

Blood glucose level (mg/dl)
Dose	0 h	1 h	2 h	4 h	6 h
NC	94.67 ± 1.18	90.32 ± 3.03	87.43 ± 3.29	84.94 ± 1.71	83.26 ± 1.72
GLC 5 mg/kg	93.32 ± 3.15	70.65 ± 3.03^a3	69.4 ± 2.21^a3b2β3	61.32 ± 1.71^a3b3β3	54.72 ± 2.95^a3b3β2
CE100 mg/kg	93.53 ± 0.94	89.21 ± 1.74	86.05 ± 1.8	82.40 ± 0.67	78.96 ± 1.88
CE200 mg/kg	92.79 ± 2.60	85.65 ± 3.01	80.49 ± 2.400^a1β1	74.34 ± 1.28^a2β2	64.66 ± 1.70^a3β3
CE400 mg/kg	91.37 ± 1.79	82.08 ± 1.00	75.76 ± 1.4^a2β2	68.94 ± 1.53^a3β3	60.57 ± 1.86^a3β3

Each value represents as mean ± SEM; n = 6 for each treatment, ^acompared to the negative control, ^bcompared to 100 mg/kg, and ^βcompared to baseline blood glucose level. ¹ < 0.05, ² < 0.01, and ³ < 0.001. NC = negative control and received 2% tween 80 indistilled water, GLC = glibenclamide, CE = crude extract.