Validation of Antidiabetic and Antihyperlipidemic Effects of 80% Methanolic Extract of the Lonchocarpus laxiflorus Leaves in Streptozotocin-Induced Diabetic Swiss Albino Mice

Table 4

The effect of the daily repeated dose of the crude extract in STZ-induced diabetic mice.

Fasting BGL (mg/dl)				% of BGL reduction
Dose	Day 0	Day 7	Day 14	7^th day	14^th day
DNC	281.01 ± 1.25	278.67 ± 2.35	276.72 ± 1.25	0.83	1.53
GCL 5 mg/kg	279.78 ± 2.7	216.89 ± 2.96^β3a3b3	194.61 ± 2.86^β3a3b3c3	22.49	30.44
CE100 mg/kg	278.84 ± 2.33	254.15 ± 1.43	250.05 ± 1.11	8.85	10.32
CE200 mg/kg	277.35 ± 2.86	237.16 ± 1.57^β3a2b2	212.02 ± 2.05^β3a3b3	14.49	23.56
CE400 mg/kg	280.67 ± 1.97	221.93 ± 1.83^β3a3b3	198.21 ± 3.36^β3a3b3c2	20.93	29.38
NNC	94.43 ± 0.98	92.49 ± 1.77	89.76 ± 2.25	2.05	4.94

Each value represents mean ± SEM; n = 6 for each treatment^,. ^βCompared to day zero (baseline blood glucose level); ^acompared to diabetes control; ^bcompared to 100 mg/kg, ^ccompared to 200 mg/kg, ¹ < 0.05, ² < 0.01, and ³ < 0.001. BGL = blood glucose level, CE = crude extract, DNC = diabetes negative control received 10 ml/kg 2% tween 80 in distilled water GLC = glibenclamide, NNC = normal negative control received 10 ml/kg 2% tween 80 in distilled water.