Research Article

Ethnomedicinal Information on Plants Used for the Treatment of Bone Fractures, Wounds, and Sprains in the Northern Region of the Republic of Benin

Table 2

Ethnobotanical uses and constituents of commonly used wound healing plants in the northern region of the Republic of Benin.

Botanical namesEthnobotanical usesMajor phytoconstituents

Adansonia digitata L.It is used as food (leaves and fruit), laxative, shelter (the tree), and in the treatment of diabetes, diarrhoea, trypanosomal diseases, and wounds [16, 17]3,3′,4′-Trihydroxyflavan-4-one-7-O-α-L-rhamnopyranoside, quercetin-7-O-β-D-xylopyranoside, 3,7 dihydroxyl-flavan- 4-one-5-O-β-D-galacto pyranosyl (1 → 4)-β-D-glucopyranoside, campesterol, stigmasterol, cholesterol, isofucosterol, ß-sitosterol, and tocopherol [18]
Aframomum melegueta (Roskoe) K. SchumSpice, flavoring agent, treatment of hemorrhoids, infections, abdominal pain, leprosy, measles, inflammatory disorders, and intestinal problems. It is used as purgative, galactogogue, and hemostatic agent [19]Vanilloids, 6-paradol, 6-gingerol, monoterpene hydrocarbons and sesquiterpenes hydrocarbons [20], benzaldehyde-3-hydroxy-4-methoxy, butan-2-one-4-(3-hydroxy-2-methoxyphenyl), flavonoids (quercetin, kaempferol, and its derivatives), triterpenoids, labdane diterpenoids, zerumin A, labdane diterpenes G3 and G5, (E)-labda-8(17), 12-diene-15, and 16-dial saponins [21]
Annona Senegalensis PersThe fruit is used for the treatment of marasmus and kwashiorkor. Treatment of diarrhoea, helminthiasis, microbial infections, snake bites, toothache, malaria, anenia, arthritis, inflammatory disorders, wound, dermatosis, and sexual impotence [22, 23]1,2 Benzenediol, butylated hydroxytoluene (BHT), phenol, 2,6-bis (1,1-dimethylethyl-4methyl), methylcarbamate, n-hexadecanoic acid, hexadecane, oleic acid, tetracosane, 9-octylheptadecane, heneicosane, 12-methyl-E, E-2, 13-octadecadien-1-ol, 13-hexyloxacyclotridec-10-en-2one, octadecanoic acid, 9, 17-octadecadienal, pentadecane, tetratriacontane and squalene [23], kaurenoic acid, and (−)-roemerine [24]
Apodostigma pallens (Planch. ex Oliv.) R.WilczekTreatment of gonorrhoea [25]
Ceiba pentandra (L.) GaertnTreatment of asthma, fever, gonorrhoea, diarrhoea, diabetes, headache, and use as aphrodisiac (barks). Diuretic and febrifuge properties (roots). The seed oil is used as fuel and lubricant [26, 27]Ceibapentains A and B, linarin, 3,4-dihydroxybenzoic acid, cinchonains ia and ib, N-trans-caffeoyl-DOPA-methyl ester, monoterpene, and sesquiterpene hydrocarbons [28, 29]
Chasmanthera dependens HochstTreatment of venereal diseases, fractures, sprains, muscular pains (leaves) and is used as uterine stimulant [30]Berberine [30], tertiary nonphenolic alkaloids (tetrahydropalmatine, liriodenine, lysicamine, oxoglaucine, glaucine, anonaine, nornuciferine, norglaucine, O,O-dimethylcorytuberine, and anomaine), govanine (= (−) -tetrahydropseudocolumbamine), coreximine, bisnorargemonine, pallidine, and quaternary alkaloids (jatrorrhizine, columbamine, pseudocolumbamine, magnoflorine, and palmatine) [31, 32]
Combretum collinum FresenTreatment of wounds, ulcers, rheumatism, microbial infections, gastrointestinal problems, cough, and bronchitis with the leaves [33]Myricetin-3-O-rhamnoside, myricetin-3-O-glucoside stilbenoids (combretastatins), phenanthrenes, and mollic acid [33]
Combretum glutinosum Perr. Ex DCTreatment of scrotal elephantiasis, dysentery, typhoid fever, eye sore and earache, fever, stomachache malaria, diarrhoea, ring worms, bronchitis, hypertension, and syphilis [34, 35]2,3-(5′)-Hexahydroxydiphenoyl-D-glucose, punicalin, punicalagin, umuhengerin and combreglutinin, betulinic acid, β-sitosterol glucoside, 5-demethylsinensetin, (20S,24R)-ocotillone, lupeol, β-sitosterol, oleanolic acid, and corymbosin [35]
Combretum sericeum G.DonTreatment of diarrhoea, gastrointestinal disorders, conjunctivitis, fever, pneumonia, malaria, and use as repellent [36, 37]
Crossopteryx febrifuga (Afzel. ex G.Don) BentsTreatment of dysentery, diarrhoea and fever [38], pain, malaria, septic wounds, and respiratory infections [39]Epimeric mixtures of 3β-urs-12,20(30)-diene-27,28-dioic acid and 18-epi-3β-urs-12,20(30)-diene-27,28-dioic acid, 3β-D-glucopyranosylurs-12,20(30)-diene-27,28-dioic acid and 18-epi-3β-D-glucopyranosylurs-12,20(30)-diene-27,28-dioic acid, triterpenoid (β-chinovin), vitexin and isovitexin xylosides, quercetin-3-rutinoside, and alkaloids (crossopterine) [40]
Eleusine indica (L.) GaertnUse as diuretic, anthelmintic, febrifuge, diaphoretic, and treatment of cough [41]Flavonoids schaftoside, vitexin, isovitexin, and 6′-O-palmitoyl derivatives, β-sitosterol, β-sitosterol glucoside, and stigmasterol [42]
Entada africana Guill. & PerrTreatment of abdominal pain, rheumatism, malaria, female infertility [43], wounds, hepatitis, bronchitis, syphilis, and bronchitis [44]Apigenin, robinetin, gallic acid, ethyl gallate, catechin, 5,7-dihydroxychromen-4-one, 3′,4′,7-trihydroxyflavone, naringenin-7-O-glucoside, myricetin-3-O-glucoside, dihydrokaempferol-7-O-glucoside, quercetin-3-O-glucoside, quercetin-3-O-(β-apiosyl-(1‴→2″)-β-glucoside), and aromadendrin [45]
Feretia apodanthera DelileTreatment of epilepsy, infantile convulsions, anxiety, psychoses, pain, inflammation, and infective wounds [46, 47]Iridoid glycosides (feretoside, gardenoside, geniposidic acid, apodanthoside, desacetylasperolosidic acid), quercetin, kaempferol, and myricetin [46, 47]
Ficus ingens (Miq.) Miq.Treatment of epilepsy, leprosy, worm sore, injuries, hemorrhoids, diarrhoea and is used as a diuretic [48]β-sitosterol, chryasophanol, 7-hydroxy-2,5 dimethylchromen-4-one, quercetin, aloe emodin glucoside, β-sitosterol glucoside, rutin, and patuletin-3′-O-methyl-3-O-rutinoside [49]
Ficus thonningii BlumeTreatment of diarrhoea, gonorrhoea, diabetes mellitus, wounds, bronchitis, urinary tract infections, stomach pains, gastritis, gastric ulcers, malaria, fever, and hepatitis [50]Orientin, vitexin and isovitexin, thonningiol, thonningiisoflavone, β-sitosterol, β-sitosterol glucoside, gancaonin G, β-amyrin acetate, friedelin, lupeol hexanoate, lupeol acetate, alpinumisoflavone, wighteone, dehydroferreirine, β-isoluteone, taxifolin, lupiwitheone hydrate, Rel (lR, 4S, 6R)-p-menthane-3,6-diol, conrauiflavonol, aromadendrin, shuterin, luteone, and hydroxyalpinumisoflavone [51]
Flueggea virosa, (Roxb. ex Willd.) RoyleTreatment of fever, malaria, pain, diabetes, epilepsy, snakebites, rheumatism, arrhythmia, sterility, rashes, diarrhoea, pneumonia, sexual dysfunction, sexual impotence, cough, HIV-related illnesses, and venereal diseases [52]Flueggenoids A–E, 13-methyl-ent-podocarpanes, and securinega alkaloids [53]
Gardenia ternifolia schumach. & ThonnTreatment of malaria, stomachache, ulcers, malaria coughs, syphilis, arthritis, asthma, epilepsy, fever, pain. Use as purgative, laxative, astringent, and antisnake venom [54]5,7-Trihydroxy-4′-methoxyflavone, 5,4′-dihydroxy-7-methoxyflavanone, 5,7-dihydroxy-3,4′-dimethoxyflavone, 3,5,3′-trihydroxy-7,4′-dimethoxyflavone, β-sitosterol and stigmasterol [54], and gardenifolins A–H [55]
Gymnosporia senegalensis, L. E. T. LoesenerTreatment of microbial infections, inflammation, tuberculosis, and respiratory diseases [56, 57]Alkaloids (ephedrine, norephedrine, stachidrine, and wilforine) maytansinoids (maytanbutine, maytanprin, and maytanbutan), phenolic compounds, triterpenes, sterols (iguestrin, lupenone, β-sitosterol), and megastigmane [56, 57]
Hannoa undulata (Guill. & Perr.) PlanchTreatment of amoebic dysentery, malaria, anemia, and intestinal diseases [58]Quassinoid (undulatone), polycyclic lactones (chaparrinone, klaineanone, and glaucarubolone), eniotorin, scopoletin, glaucarubinone, and 15-desacetylundulatone [58, 59]
Hymenocardia acida, TulTreatment of eye infection, sickle cell anemia, chest complaints, abdominal and menstrual pains, trypanosomiasis, coughs, hemorrhoids, stomachaches, microbial infections, asthma, and fractures [60]Triterpenoids and sterols (friedelan-3-one, betulinic acid, stigmasterol, lupeol, β-sitosterol), fatty acid (oleic acid), hymenocardine, and hymenocardinol [61]
Ipomoea pyrophila, A. Cheval
Jatropha curcas L.Treatment of eczema, skin diseases, rheumatic muscular pains, inflammation and is used as fuel [62]Organic acids, cyclic triterpenes, stigmasterol, β-sitosterol, curcin, apigenin, vitexin, and isovitexin [63]
Lannea microcarpa, A. RichTreatment of fever, gastrointestinal problems, wounds, respiratory problems, ulcers, pain, malaria, musculoskeletal disorders, hemorrhoids, skin diseases and is used in ethnoveterinary medicine [64]Epicatechin, myricetin glycosides, gallic acid, isovitexin, and cyanidin 3-O-β-D-galactopyranoside [64]
Maerua angolensis, DC.Treatment of pain, cancer, fever, malaria, gastrointestinal problems, sores, and wounds [65]Tannins, saponins, flavonoids, cardiac glycosides, and alkaloids [65]
Newbouldia laevis seemTreatment of malaria, stomachache, toothache, wound dysentery, sexual transmitted disease (syphilis), migraine, and sexual impotency [66, 67]Pyrazole alkaloids (withasomnine, 4′-hydroxywithasomnine, 4′-methoxywithasomnine, newbouldine, and 4′-hydroxynewbouldine), newbouldiosides D-F, 7-hydroxydehydroiso-α-lapachone, 5,7-dihydroxydehydroiso-α-lapachone and 3-hydroxy-5-methoxydehydroiso-α-lapachone, and 6-hydroxydehydroiso-α-lapachone [6870]
Ochna rhizomatosa (van tiegh.) KeayTreatment of intestinal helminthiasis, jaundice, malaria, wounds, and typhoid fever [71, 72](R)-Rhizomatobiflavonoid A-C, gerontoisoflavone A, schweinfurthianone A, shweinfurthianone B, and calodenine B [73]
Ochna schweinfurthiana (van tiegh.) KeayTreatment of rubella, fungal skin infections, burns, stomachache, sclerosis, malaria, helminthiasis, typhoid fever, measles, and wounds [7476]Agathisflavone, cupressuflavone, sucrose, calodenone, calodenine B, robustaflavone, lophirone A, gerontoisoflavone A, amentoflavone, hemerocallone, 16α,17-dihydroxy-ent-kauran-19-oic acid and 3β-O-D-glucopyranosyl-β-sitosterol, 6,7-dimethoxy-3′,4′-dimethoxyisoflavone, epicatechin lithospermoside, and 3β-O-D-glucopyranosyl-β-stigmasterol [77]
Ozoroa pulcherrima (schweinf.) R. & A.Treatment of asthenia, helminthiasis, conjunctivitis, chest pain, dystocia, hyperthermia, and conjunctivitis. It is used after childbirth to increase lactation [7880]Ozocardic A, 6-tridecyl anacardic acid, β-sitosterol, and ozoromide [7880]
Paullinia pinnata, LinnTreatment of snake bites, rabies, mental problems, blindness and eye troubles, paralysis, eczema, wounds, threatened abortion, malaria, ancylostomiasis, to expel placenta and gonorrhoea. [81]3-Oxo-11α-hydroxyl-20-lupene, lupeol-3-isovanniloyl ester, 5α-portiferastane-3β,6α-diol and 2-(4-hydroxyl-3,5-dimethoxyl phenyl)-3-hydroxymethyl-2,3-dihydro-1,4,5-trioxaphenanthrene-6-one, lupeyl steryl ether [82]
Piliostigma thonningii, (schum.) Milne-RedhTreatment of malaria, leprosy, wounds, ulcers, gingivitis, fever, cough, toothache, sore throat [83]
Treatment of dysentery, diarrhoea, inflammation, skin diseases, and intestinal problems [8486]
4-Hydroxybenzoic acid, piliostigmin, afzelin, quercitrin, 7 (9-desoxy-α-conidendrin, quercetin-3-O-rhamnoside, 2β-methoxyclovan-9α-ol, and methyl-ent-3β-hydroxylabd-8(17)-en-15-oate, (3αR,9R,9αs)-7-hydroxy-9(4-hydroxy-3-methoxyphenyl)-6-methoxy-3α,4,9,9α-tetrahydro-1H benzo[f] [2] benzo-furan-3-onenabellamide), 3,4-dihydroxybenzoic acid, (2E)-3-(4-hydroxy-3-methoxyphenyl) prop-2-enoic acid, and 8-(β-D-glucopyranosyl)-4′,5,7-trihyroxyflavone [84, 85]
Rourea coccinea (schumach. & Thonn.) BenthTreatment of paralysis, Alzheimer’s disease, snakebites, sexual asthenia, furuncles, malaria, joint pains, asthma, male and female infertility, and blennorrhoea [87]
Sarcocephalus latifolius, J. E. Smith et E.A. BruceTreatment of fever, toothache, dental cures, septic mouth, diarrhoea, and dysentery; used as chewing stick [88]Indole alkaloids (augustine, nauclifine, augustidine, 21-O-methylstrictosamideaglycone, 19-O-ethylaugustoline, naucleidinal, 19-epinaucleidinal), β-sitosterol, tramadol, naucleamide, quinovic acid-3β-O-β-D-fucopyranoside, quinovic acid-3β-O-β-D-rhamnopyranoside, and scopoletin [88, 89]
Vitellaria paradoxa C.F.Gaertn. ssp. paradoxaTreatment of cancer, diarrhoea, hemorrhoids, cough, tuberculosis, infectious diseases, headache hypertension, malaria and is used to relieve labor and delivery pains [90]Triterpene acids of oleanane-type and glycosides (paradoxosides A-E, parkiosides A-C, tieghemelin A), flavonoids (catechin, gambiriin C, luteolin-7-glucoside, myricitrin, quercetin) [90]
Vitex doniana sweetTreatment of diabetes, high blood pressure, ulcers, swellings, and oedema [91]2,3-Acetonide-24- hydroxyecdysone, 21-hydroxyshidasterone, 11β-hydroxy-20-deoxyshidasterone, ajugasterone, 11β,24-hydroxyecdysone, ecdysteroids shidasteron, and 24-hydroxyecdysone [92]
Xylopia aethiopica (Dunal) A. RichTreatment of menstrual disorder, naso-pharyngeal infections, arthritis, rheumatism, diarrhoea, dysentery, cough, malaria, uterine fibroid, wounds, and stomach disorder [93, 94]Diterpenes (15-oxo-(−)-trachyloban-19-oic acid, (−)-kaur-15-en-17-al-19-oic acid), and terpenes [95]