Research Article
Electroacupuncture Modulates 5-HT4R-Mediated cAMP/PKA Signaling to Improve Intestinal Motility Disorders in a Thy1-αSyn Parkinson’s Mouse Model
Figure 1
Thy1-αSyn transgenic mice had motor impairment and intestinal motility disorder, and electroacupuncture significantly improved the fecal output and small-intestinal propulsion. (a) Overall rotarod performance (ORP) scores. (b) Total fecal pellets produced in 15 min. (c) Fecal output at different time intervals within the detection period. (d, e) Small-intestine propulsion and representative images showing the dissected intestines of mice in the normal control (N), PD model (M), electroacupuncture (EA), and western medicine (WM) groups. ∗ and ∗∗ relative to the normal control group; # and ## relative to the PD model group.
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