Study ID Name of TCM therapy and delivery (dosage for 1 use/usage/frequency) Composition of CHM Jiang F, 2009 [18 ] Long Dan Xie Gan granules: 6 g/po./tid Long Dan Xie Gan granules: Gentianae Radix et Rhizoma (longdan), Gardeniae Fructus (zhizi), Scutellariae Radix (huangqin), Bupleuri Radix (chaihu), Rehmanniae Radix (shengdi), Plant Aginis Semen (cheqianzi-with hot salt frying), Alismatis Rhizoma (zexie), Aristolochia Manshuriensis (guanmutong), Angelicae Sinensis Radix (danggui-with hot alcohol frying), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (zhigancao) Ruyi Jinhuang paste (external): q.s./p.a.a./bid. or tid Ruyi Jinhuang paste (external): Trichosanthis Radix (tianhuafen), Curcumae Longae Rhizoma (jianghuang), Paeoniae Radix Alba (baizhi), Atractylodis Rhizoma (cangzhu), Arisaemants Rhizoma (tiannanxing), Glycyrrhizae Radix et Rhizoma (gancao), and Rhei Radix et Rhizoma Meng L, 2006 [19 ] Long Dan Xie Gan granules: 6 g/po./tid Long Dan Xie Gan granules: (same as Jiang F 2009) Ruyi Jinhuang paste (external): q.s./p.a.a./bid. or tid Ruyi Jinhuang paste (external): (same as Jiang F 2009) Yu F, 2013 [20 ] Tanreqing injection: 20 ml/5% GS 250 ml ivgtt./qd Tanreqing injection: Scutellariae Radix (huangqin), Pulvis Fellis Ursi (xiongdanfen), capra hircus cornu (shanyangjiao), Lonicerae Japonicae Flos (jinyinhua), Fructus Forsythiae (lianqiao), etc. Excipients: propylene glycol CHM wash lotion: 1,000∼2,000 mL/p.a.a. for 20∼25 min/bid CM wash lotion: Sophorae Flavescentis Radix (kushen), Rehmanniae Radix (shengdi), Phellodendri Chinensis Cortex (huangbo), Corydalis Rhizoma (yuanhu, duanmuli, wubeizi), Lonicerae Japonicae Flos (jinyinhua, tufuling), Taraxaci Herba (pugongying), Alumen (baifan), Alismatis Rhizoma (zexie), and Borneolum (bingpian) Duan XW, 2011 [21 ] Long Dan Xie Gan granules: unknown/po./bid Long Dan Xie Gan granules: Gentianae Radix et Rhizoma (longdan), Gardeniae Fructus (zhizi), Scutellariae Radix (huangqin), Bupleuri Radix (chaihu), Rehmanniae Radix (shengdi), Plant Aginis Semen (cheqianzi-with hot salt frying), Alismatis Rhizoma (zexie), Tetrapanacis Medulla (tongcao), Glycyrrhizae Radix et Rhizoma (gancao), Paeoniae Radix Rubra (chishao), Toosendan Fructus (chuanlianzi), Artemisiae Scopariae Herba (yinchen), and Lonicerae Japonicae Flos (jinyinhua) Zeng L, 2005 [22 ] Long Dan Xie Gan granules: elixation/po./bid Long Dan Xie Gan granules: unknown Jidesheng sheyao tablets (external): grind into powder and mix with water to make paste, q.s./p.a.a./q3h Jidesheng sheyao tablets (external): Paridis Rhizoma (chonglou), Scolopendra (wugong), Euphorbiae Humifusae Herba (dijincao), etc. Liang FL, 2012 [23 ] Herbal gargle: add 500 mL water boil to 250 mL elixation/p.a.a. 20∼25 min/bid (patients with oral herpes) 30–50 ml/Garg.3∼5 min/bid Herbal gargle: Sophorae Flavescentis Radix (kushen), Rehmanniae Radix (shengdi), Scrophulariae Radix (xuanshen), Ophiopogonis Radix (maidong), Adenophorae Radix or Glehniae Radix (shashen), Gynostemma Pentaphyllum (jiaogulan), Ilexasprella Radix (gangmeigen), and Coptidis Rhizoma (huanglian) Wang Q, 2014 [24 ] Long Dan Xie Gan formula or Ba Zhen formula: elixation/po./bid Long Dan Xie Gan formula: Gentianae Radix et Rhizoma (longdan), Gardeniae Fructus (zhizi), Scutellariae Radix (huangqin), Bupleuri Radix (chaihu), Rehmanniae Radix (shengdi), Plant Aginis Semen (cheqianzi-with hot salt frying), Alismatis Rhizoma (zexie), Tetrapanacis Medulla (tongcao), Polygoni Cuspidate Rhizome et Radix (huzhang), Arneblae Radix (zicao), and Lonicerae Japonicae Flos (jinyinhua) Ba Zhen formula: Rehmanniae Radix Praeparata (shudi), Codonopsis Radix (dangshen), Atractylodis Macrocephalae Rhizoma (jiaobaizhu), Angelicae Sinensis Radix (dangui), Chuanxiong Rhizoma (chuanxiong), Paeoniae Radix Alba (chaobaishao), Saposhnikoviae Radix (fangfeng), Poria (fuling), Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (zhigancao), Polygoni Cuspidate Rhizome et Radix (huzhang), Arneblae Radix (zicao), and Lonicerae Japonicae Flos (jinyinhua) Shao Z, 2011 [25 ] Long Dan Xie Gan formula or chushi Longda nxiegan formula: (Same as duan XW 2011) Weiling formula: elixation half dose/po./bid Chu Shi Wei Ling formula: Atractylodis Rhizoma (cangzhu), Atractylodis Macrocephalae Rhizoma (baizhu), Toosendan Fructus (chuanlianzi), Citri Reticulatae Pericarpium (chenpi), Polyporus (zhuling), Poria (fuling), Alismatis Rhizoma (zexie), Tetrapanacis Medulla (tongcao), Coicis Semen (yiyiren), Astragali Radix (huangqi), Codonopsis Radix (dangshen), Corydalis Rhizoma (yuanhu), Scolopendra (wugong), and Glycyrrhizae Radix et Rhizoma (gancao) Sanhuang wash lotion: q.s./po./unknown Sanhuang wash lotion: Phellodendri Chinensis Cortex (huangbo), Portulacae Herba (machixian), indigo naturalis (qingdai), excipients: sesame oil Pan HR, 2010 [26 ] Long Dan Xie Gan formula and chushi Long Dan Xie Gan formula: (same as Duan XW, 2011, Shao Z, 2011) Weiling formula: elixation/po./bid Chu Shi Wei Ling formula: (same as Shao Z, 2011) Sanhuang wash lotion: q.s./po./unknown Sanhuang wash lotion: (same as Shao Z, 2011) Wu JL, 2011 [27 ] Long Dan Xie Gan formula or chushi weiling formula: elixation/unknown/unknown Longda nxiegan formula: unknown Chu Shi Wei Ling formula: unknown Method/specifications/retention time Operating site/acupoint selection Liu ZW, 2013 [28 ] Encircling needling/0.38 mm Acupuncture: surround needling for herpes periphery/no special acupoint Jingwanhong burn ointment: q.s./po./after thread-moxa Thread-moxa: for small herpes clusters/main acupoint: ashi points; matching points: zusanli (st36, bilateral) and guanyuan (rn4). after thread-moxa apply jingwanhong burn ointment on herpes, for big herpes prick before applying. composition of jingwanhong burn ointment: unknown Li M, 2000 [29 ] Regular moxibustion: unknown/31 min Moxibustion: herpes area/no special acupoint Blood-letting puncture: three-edged needle/several drops of blood Blood-letting puncture: healthy skin around herpes/no special acupoint Reducing acupuncture method: 0.38 mm Reducing acupuncture method: determined acupoint/fengchi (GB20), quchi (LI11), hegu (LI4), taichong (LR3), zusanli (ST36), yinlingquan (SP9), and sanyinjiao (SP6) Encircling needling + reducing acupuncture method: 0.38 mm Encircling needling: healthy skin around herpes/needling around herpes, each needle interval for 5 cm/no special acupoint Transverse needling: 0.38 mm Transverse needling: inside herpes range/needling on herpes lesion area, each needle interval for 5 cm side by side/no special acupoint
