The Effects of Qinghao-Kushen and Its Active Compounds on the Biological Characteristics of Liver Cancer Cells

Figure 4

Matrine and scopoletin targeted GSK-3β by analyzing herb-compound-target-pathway networks. (a) Protein-protein interaction analysis. Larger nodes represent a higher degree of the targets, red represents the largest degree, and yellow represents a minor degree. (b) Herb-compound-target-pathway interaction network (H-C-T-P network). The node size is expressed in terms of degree. The larger the degree value, the larger the shape of the graph. (c) The binding mode of GSK-3β with matrine. (d) The binding mode of GSK-3β with scopoletin. The backbone of protein was rendered in tube and colored in blue. The compound is rendered in yellow. Yellow dash represents hydrogen bond distance.

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