Caffeic Acid Prevents Vascular Oxidative Stress and Atherosclerosis against Atherosclerogenic Diet in Rats

Table 1

Effects of caffeic acid (CA) against atherogenic diet- (Ath-) induced alteration(s) in blood biochemistry.

Group	Cholesterol (mg/dL)	HDL (mg/dL)	LDL (mg/dL)	VLDL (mg/dL)	TG (mg/dL)	LDH (IU/L)	ALT (IU/L)	AST (IU/L)	AIP
Control	157.2 ± 1.515	65.17 ± 0.307	74.16 ± 0.477	30.17 ± 0.477	120.1 ± 0.167	130.1 ± 0.307	80.5 ± 0.428	9 ± 0.365	1.6 ± 1.141
Ath control	321.5 ± 2.861^a	25.17 ± 0.307^a	212.3 ± 0.615^a	62.5 ± 0.563^a	346 ± 0.365^a	345.3 ± 0.307^a	131 ± 0.365^a	51.33 ± 0.365^a	10.7 ± 0.23^a
Ath + CA (25 mg/kg)	238.5 ± 3.442^z	35.0 ± 0.3651^z	139.8 ± 0.477^z	42.5 ± 0.428^z	250.83 ± 0.307^z	236.5 ± 0.31^z	119.16 ± 0.494^z	31 ± 0.516^z	5.4 ± 1.374^z
Ath + CA (50 mg/kg)	187.2 ± 2.926^z	48.5 ± 0.2236^z	109.6 ± 0.558^z	37 ± 0.447^z	160.8 ± 0.401^z	191.8 ± 0.308^z	97.83 ± 0.365^z	22 ± 0.364^z	3.13 ± 1.137^z
Control + CA (50 mg/kg)	157.8 ± 2.428	67.0 ± 0.333	70.8 ± 0.428	28.5 ± 0.429	119.6 ± 0.494	128 ± 0.365	78 ± 0.365	7 ± 0.966	1.4 ± 1.031
Ath + ATORVA (5)	131.7 ± 2.076^z	48.0 ± 0.365^z	92.5 ± 0.5^z	33.6 ± 0.333^z	131.1 ± 0.307^z	161 ± 0.365^z	88.3 ± 0.364^z	18.1 ± 0.477^z	2.5 ± 0.118^z

Values are expressed as mean ± S.E.M. ^avs. the control group, ^zvs. the Ath control group. Data are analyzed using one-way ANOVA followed by Tukey’s HSD post hoc test. HDL : high-density lipoprotein, LDL : low-density lipoprotein, VLDL : very-low-density lipoprotein, TG : triglyceride, AIP : atherogenic index in plasma.