Mechanistic Insights of Qingre Jiedu Recipe Based on Network Pharmacology Approach against Heart Failure

Figure 1

Efficacy evaluation after QJ recipe treatment. (a) Echocardiography was conducted to detect cardiac function in sham, model, and QJ groups. (b) Echocardiography data showed that QJ treatment could increase EF and FS values and decrease LVID; s and LVID; d values. (c) HE staining showed that QJ treatment alleviated inflammatory responses, scale bar = 50 μm. (d, e) Masson staining and Sirius-red staining showed that QJ treatment attenuated collagen deposition and fibrotic remodeling, scale bar = 50 μm. (f–i) Levels of IL-1, IL-6, peptide of type III procollagen (PIIINP), and collagen IV (CIV) in serum. QJ treatment could alleviate inflammatory responses and reduce myocardial fibrosis. Data were presented as the mean ± standard error of three independent experiments (N = 8 per group; , ).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)