Bushen Jianpi Quyu Formula Alleviates Myelosuppression of an Immune-Mediated Aplastic Anemia Mouse Model via Inhibiting Expression of the PI3K/AKT/NF-κB Signaling Pathway

Figure 6

Effect of BSJPQYF on PI3K, AKT, p-AKT, NF-κB, p-NF-κB, TNF-α, and cleaved caspase-3 in BMSCs of mice. Groups from left to right, respectively: control group, model group, low dose (0.85 g/mL BSJPQYF) group, and high dose (1.7 g/mL BSJPQYF) group. (a) Protein bands of PI3K, AKT, p-AKT, NF-κB, p-NF-κB, and TNF-α. (b) Quantitative analysis of PI3K, AKT, p-AKT, NF-κB, p-NF-κB, and TNF-α expression alteration in BMSCs of mice. (c) Protein band of cleaved caspase-3. (d) Quantitative analysis of cleaved caspase-3 expression alteration in BMSCs of mice. Data are expressed as mean ± standard deviation (n = 3). versus the control group; versus the model group.

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