In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile of Gynura procumbens Leaves

Table 10

Binding affinity of natural ligands of G. procumbens with the crystal target of N-glucosidase.

Compound name	Binding affinity	Class of compound
Nicotiflorin	−9.3	Flavonoid
Rutin	−9.2	Flavonoid
Beta-stigmasterol	−9.1	Steroid
5α-Stigmastan-3-one	−8.8	Steroid
3,4-Dicaffeoylquinic acid	−8.7	Phenol
4,5-Dicaffeoylquinic acid	−8.7	Phenol
Eriocitrin	−8.7	Flavonoid
Glucopyranosyl stigmasterol	−8.5	Steroid
1,5-Dicaffeoylquinic acid	−8.5	Phenol
1,4-Dicaffeoylquinic acid	−8.3	Phenol
3,5-Dicaffeoylquinic acid	−8	Phenol
Astragalin	−7.7	Flavonoid
Luteolin	−7.6	Flavonoid
Myricetin	−7.6	Flavonoid
Feruloylquinic acid	−7.5	Phenol
Chlorogenic acid	−7.5	Phenol
Negletein	−7.5	Flavonoid
Quercetin	−7.5	Flavonoid
Apigenin	−7.5	Flavonoid
Neochlorogenic acid	−7.5	Phenol
Glucuronide	−7.5	Phenol
Homoorientin	−7.4	Flavonoid
Kaempferol	−7.4	Flavonoid
Caffeoylglucaric acid	−7.3	Phenol
Hydroxytyrosol glucoside	−7.2	Phenol
Daucosterol	−7.2	Steroid
Senecionine-N-oxide	−7.1	Alkaloids
Senkirkine	−7	Alkaloids
Seneciphylline-N-oxide	−6.9	Alkaloids
Acarbose	−6.7	Reference