In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile of Gynura procumbens Leaves

Table 5

Effect of G. procumbens on the activities of glycolytic enzymes in the liver of control and experimental rats.

Group	Hexokinase (n moles of glucose-6-phosphate formed/min/mg/protein)	Aldolase (n moles of glyceraldehyde formed/min/mg protein)	Phosphoglucoisomerase (n moles of fructose formed/min/mg protein)
C	397.26 ± 7.39	156.3 ± 7.13	49.32 ± 5.49
A	103.36 ± 5.86	244.82 ± 30.7	27.32 ± 4.55
A + M100	228.62 ± 15.97^∗	201.9 ± 11.56^∗	33.28 ± 4.95^∗
A + M200	333.8 ± 11.20^∗	176.14 ± 8.75^∗	41.24 ± 1.63^∗
A + M500	401.4 ± 10.05^∗	155.86 ± 14.2^∗	49.28 ± 3.40^∗
A + G500	213.86 ± 12.20^∗	210.86 ± 9.94^∗	30.4 ± 4.21^∗
A + G750	325.9 ± 11.05^∗	192.12 ± 11.25^∗	38.64 ± 1.50^∗
A + G1000	378.56 ± 21.88^∗	157.64 ± 8.20^∗	47.38 ± 2.30^∗
M100	391.24 ± 8.56	161.74 ± 6.95	46.74 ± 6.56
M200	393.16 ± 8.91	152.58 ± 7.07	50.04 ± 4.43
M500	395.64 ± 6.87	151.68 ± 6.34	47.7 ± 3.08
G500	396.44 ± 8.34	161.92 ± 5.79	48.76 ± 3.98
G750	388.14 ± 2.53	159.62 ± 11.89	49.06 ± 4.04
G1000	397.68 ± 7.185	150.08 ± 2.85	50.78 ± 3.64

^∗ indicates a significant difference from the disease group (C = control group, A = alloxan-treated group, M = metformin, A + M = alloxan + metformin, A + G = alloxan + Gynura, and G = G. procumbens).