In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile of Gynura procumbens Leaves

Table 6

Effect of G. procumbens on the activities of glycolytic enzymes in the kidney of control and experimental rats.

Group	Hexokinase (n moles of glucose-6-phosphate formed/min/mg/protein)	Aldolase (n moles of glyceraldehyde formed/min/mg protein)	Phosphoglucoisomerase (n moles of fructose formed/min/mg protein)
C	291.64 ± 10.52	222.7 ± 13.64	31.64 ± 3.67
A	82.7 ± 5.05	286.26 ± 19.86	18.48 ± 2.90
A + M100	152.46 ± 6.88^∗	263.86 ± 11.38^∗	24.36 ± 2.31^∗
A + M200	234.1 ± 7.3^∗	243.06 ± 10.98^∗	27.02 ± 2.99^∗
A + M500	274.94 ± 9.61^∗	229.54 ± 4.75^∗	30.3 ± 1.77^∗
A + G500	142.32 ± 10.59^∗	267.5 ± 6.04^∗	24.98 ± 2.08^∗
A + G750	221.92 ± 7.69^∗	241.94 ± 10.34^∗	30.16 ± 2.26^∗
A + G1000	260.28 ± 8.788^∗	224.68 ± 7.75^∗	28.68 ± 2.07^∗
M100	292.56 ± 17.18	225.74 ± 9.55	28.4 ± 3.09
M200	290.56 ± 8.18	212.58 ± 2.27	29.62 ± 2.83
M500	288.36 ± 9.30	225.38 ± 7.98	30.7 ± 1.93
G500	291.16 ± 6.76	219.34 ± 7.28	29.98 ± 1.23
G750	288 ± 13.13	223.74 ± 8.75	32 ± 1.86
G1000	279.6 ± 12.72	219.42 ± 8.52	32.8 ± 2.07

^∗ indicates a significant difference from the disease group (C = control group, A = alloxan-treated group, M = metformin, A + M = alloxan + metformin, A + G = alloxan + Gynura, and G = G. procumbens).